Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,000 | |||
2 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 39,500 | |||
10 mg | 在庫あり | ¥ 62,500 | |||
25 mg | 在庫あり | ¥ 111,000 | |||
50 mg | 在庫あり | ¥ 158,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 49,000 |
説明 | CUDC-427 (GDC-0917) is an orally bioactive and pan antagonist of inhibitor of apoptosis proteins(IAPs). CUDC-427 can be used in research on cancers. |
In vitro | In PBMCs, GDC-0917 (0.1 -10000 nM) induces the reduction of cIAP1 levels in a concentration-dependent manner. GDC-0917(0.1 µM) shows more than 80% inhibition[1]. |
In vivo | In the MDA-MB-231-X1.1 Breast Cancer Xenograft, GDC-0917 (0.08-16.3 mg/kg) dose-dependently exhibits antitumor activity with a <11% decrease of body weight. The clearance values are 12.0, 27.0, 15.3 and 67.6 mL/min/kg for mouse, rat, dog and monkey[1]. |
別名 | GDC-0917 |
分子量 | 564.7 |
分子式 | C29H36N6O4S |
CAS No. | 1446182-94-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (79.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CUDC-427 1446182-94-0 Apoptosis IAP GDC0917 GDC 0917 CUDC427 GDC-0917 CUDC 427 Inhibitor inhibitor inhibit