Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,000 | |||
10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 17,500 | |||
50 mg | 在庫あり | ¥ 27,000 | |||
100 mg | 在庫あり | ¥ 40,000 | |||
500 mg | 在庫あり | ¥ 98,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively) |
ターゲット&IC50 | D2 receptor:0.49 nM (Ki) , 5-HT1A receptor:2.6 nM (Ki), D3 receptor:0.085 nM (Ki) |
In vivo | Cariprazine occupied D(2)/D(3) receptors in a dose-dependent and saturable manner, with the lowest dose occupying ~5% of receptors and the highest dose showing more than 90% occupancy. 5-HT(1A) receptor occupancy was considerably lower compared with D(2)/D(3) occupancy at the same doses, with a maximal value of ~30% for the raphe nuclei[1]. |
動物実験 | Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1]. |
別名 | Cariprazine HCl, RGH188 hydrochloride |
分子量 | 463.87 |
分子式 | C21H33Cl3N4O |
CAS No. | 1083076-69-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1mg/ml (insoluble), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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