Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.
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10 mg | 在庫あり | ¥ 7,500 | |||
25 mg | 在庫あり | ¥ 11,500 | |||
50 mg | 在庫あり | ¥ 15,000 | |||
100 mg | 在庫あり | ¥ 26,000 | |||
200 mg | 在庫あり | ¥ 45,500 | |||
500 mg | 在庫あり | ¥ 77,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator. |
In vitro | Cinepazide exhibits strong chronotropic and inotropic effects. Intravenous administration of Cinepazide (1 mg/kg - 3 mg/kg) leads to an 8% increase in heart rate while reducing blood pressure by 4%. Cinepazide selectively enhances the functional activity of 5-HT neurons in the brain, although hypoxia inhibits its activity. Doses of Cinepazide (3 mg/kg - 30 mg/kg) administered intravenously transiently increase renal and femoral arterial blood flow, spinal and carotid blood flow, and cardiac output in anesthetized dogs while decreasing total peripheral resistance, exhibiting a concentration-dependent relationship with these effects. At 30 mg/kg, Cinepazide enhances the dilatory neural response of dog spinal blood vessels to intrathecal adenosine and adenylic acid. Cinepazide (1 mg - 10 mg) amplifies blood flow within spinal vessels in a dose-dependent manner, partially inhibited by pretreatment with intravenous aminophylline and unaffected by autonomic antagonists. Cinepazide is well absorbed, with over 60% excreted within 24 hours. Over five days, the excretion of Cinepazide through feces and urine is 58.3% and 36.7% in rats, 68.6% and 33.4% in dogs, and 38.1% and 61.3% in humans, respectively. |
別名 | MD-67350, Vasodistal, Brendil |
分子量 | 533.57 |
分子式 | C22H31N3O5·C4H4O4 |
CAS No. | 26328-04-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: 98 mg/mL (183.7 mM)
DMSO: 99 mg/mL (185.5 mM)
You can also refer to dose conversion for different animals. 詳細
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Cinepazide maleate 26328-04-1 Membrane transporter/Ion channel Metabolism Calcium Channel stroke Inhibitor brain?infarct Cinepazide Maleate MD-67350 Ca2+ channels Cinepazide piperazine derivative Ca channels MD 67350 vasodilator cerebrovascular disease ischemic Vasodistal MD67350 Brendil inhibit inhibitor