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天然化合物

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カタログ番号	製品名	別名	ターゲット
TP1856	Colivelin		Beta Amyloid , STAT
	Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).		Beta Amyloid , STAT
T15130	Dilazep dihydrochloride		Others
	Dilazep dihydrochloride is an adenosine uptake inhibitor. It also inhibits ischemic damage, membrane transport of nucleosides, and platelet aggregation. It has cerebral and coronary vasodilating action through the enhanc...		Others
T22749	DR2313	DR 2313	PARP
	DR2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (IC50: 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). It also has neuroprotective.		PARP
T2423	P7C3-A20		Others
	P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.		Others
T7946	AER-271		Aquaporin
	AER-271 is an inhibitor of aquaporin-4.		Aquaporin
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T8869	B355252		Others
	B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth.		Others
T5326	Sugammadex sodium	Org25969,Sugammadex (sodium)	Others
	Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.		Others
T3074	CHIR 98024	CHIR98014	GSK-3 , S6 Kinase
	CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.		GSK-3 , S6 Kinase
T20843	Aplodan	Nergize,Creatinolfosfate,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate	Others
	Aplodan (creatinol-O-phosphate) exhibits antiischemic and antiarrhythmic capacity and protective action on the cell membrane. Aplodan can be used in research on the ischemic heart or ischemic heart disease with persisten...		Others
T23146	PHA 568487 free base	PHA 568487	AChR
	The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia...		AChR
T0368	Cinepazide maleate	MD-67350,Vasodistal,Brendil	Calcium Channel
	Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.		Calcium Channel
T0154	Nebivolol hydrochloride	R 065824 hydrochloride,Nebivolol HCl,R-65824	Apoptosis , Adrenergic Receptor
	Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine/ NITRIC OXIDE system. It is us...		Apoptosis , Adrenergic Receptor
T6595	Moexipril hydrochloride	Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis , RAAS
	Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.		Apoptosis , RAAS
T39195	YM-244769 dihydrochloride		Calcium Channel
	YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.		Calcium Channel
T9888	YM-244769	3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-	Calcium Channel
	YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effec...		Calcium Channel
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T29687	Afacifenacin	Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986	AChR
	Afacifenacin (SMP-986) fumarate is an M3 muscarinic receptor-selective antagonist used in the study of ischemic heart disease, urinary incontinence and cystitis and other disorders.		AChR
T39463	Asundexian	BAY 2433334,Asundexian,BAY2433334,BAY-2433334	Factor Xa
	Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 n...		Factor Xa
T26645	Aptiganel	CNS 1102,CNS-1102,CNS1102	NMDAR
	Aptiganel (CNS-1102) is a non-competitive NMDA antagonist, a peptide that may be used to study acute ischemic stroke.		NMDAR
T77442	Glenzocimab	ACT017	Others
	Glenzocimab (ACT017) is a Fab fragment of a humanized anti-GPVI monoclonal antibody. Glenzocimab demonstrated inhibition of collagen-induced platelet aggregation in an ischemic stroke model. Glenzocimab has been studied ...		Others
T0988	Trimetazidine dihydrochloride	Yoshimilon,Kyurinett,Vastarel F	Autophagy , Fatty Acid Synthase
	Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in isch...		Autophagy , Fatty Acid Synthase
T27630	Isbogrel	CV4151,CV-4151,CV 4151	Prostaglandin Receptor
	Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks and thrombosis.		Prostaglandin Receptor
T0080	Trapidil	Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR , PDE
	Trapidil (Avantrin) is a coronary vasodilator agent. It was originally developed as a vasodilator and anti-platelet agent and has been used to treat patients with ischemic coronary heart, liver, and kidney disease.		PDGFR , PDE
T77611	DAPK-IN-2	WAY-380496	DAPK
	DAPK-IN-2 (WAY-380496) is a DAPK inhibitor. DAPK-IN-2 has potential anticancer activity, regulates autophagy and can be used to study cerebral infarction and ischemic diseases.		DAPK
T28607	Rocepafant	LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation
	Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor...		Platelet aggregation
T24115	GSK854	GSK-854,GSK 854	Apoptosis
	GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,...		Apoptosis
T60507	Utreloxastat
	Utreloxastat is a compound used to study diseases including alpha-synucleinopathies, tauopathies, ALS, traumatic brain injury, and ischemic-reperfusion related injuries.
T7355	IC87201		Others , iGluR
	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.		Others , iGluR
T21757	BRL 52537 hydrochloride		Opioid Receptor
	BRL 52537 hydrochloride is a selective and specific KOR agonist which has been implicated in neuroprotection from ischemic neuronal injury[1]. It is used for research into potential treatments for stroke and heart attack...		Opioid Receptor
T24239	K201	K-201,JTV 519,JTV-519,K 201	Calcium Channel
	K201 (JTV-519) is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors.		Calcium Channel
T90611	PF-03049423
	PF-03049423 is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of approximately 0.2 nM for rat and human thrombomodulin. PF-03049423 can be used in studies about acute ischemic stroke studies.
T29645	Adatanserin hydrochloride	WY50324 hydrochloride	5-HT Receptor
	Adatanserin hydrochloride (WY50324 hydrochloride) is a novel 5-HT(1A)/5-HT(2) receptor ligand with potential neuroprotective effects and inhibition of ischemic efflux of endogenous amino acids, which can be used in the s...		5-HT Receptor
T78141	LFHP-1c		Phospholipase
	LFHP-1c, a neuroprotective PGAM5 inhibitor, demonstrates efficacy in preserving blood-brain barrier integrity following ischemic stroke. It achieves this by binding to endothelial PGAM5, thereby inhibiting its phosphatas...		Phospholipase
T21509	CA 074		Cysteine Protease
	CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom...		Cysteine Protease
T3527	TRC051384	TRC 051384	HSP
	TRC051384 is a heat shock protein 70 (HSP70) inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke, activates heat shock factor-1 and leads to elevated ...		HSP
T36569	KR-32568		Sodium Channel
	KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM). KR-32568 exhibits potent cardioprotective effects. When used at a concentration of 10 μM, it restored cardiac systolic function in an isolated i...		Sodium Channel
T21871	MMPSI	Caspase-3/7 Inhibitor I	Apoptosis , Caspase
	MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a ...		Apoptosis , Caspase
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
T31206	Darexaban	YM 150,Darexaban, Tanexaban,YM150	Factor Xa
	Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...		Factor Xa
T50100	3-hydroxy-3-phenylpentanamide		Others
	3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In p...		Others
T70540	Pinokalant	LOE-908	SARS-CoV , TRP/TRPV Channel
	Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem...		SARS-CoV , TRP/TRPV Channel
T36503	Sodium Hydrogen Sulfide (hydrate)		Others
	Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sul...		Others
T26018	R 59494	R-59494,R59494
	R 59494 is a novel anti-ischemic molecule.
T25722	Lifarizine methanesulfonate
	Lifarizine methanesulfonate is a modulator of sodium-calcium channel that reduces ischemic brain damage.
T13642	Deloxolone	(3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid	Others
	Deloxolone shows potential in treating inflammatory, ischemic, and proliferative diseases.		Others
T28646	S-312-d	S312-d,S 312-d,S-312d,S 312d
	S-312d is a calcium channel antagonist. S-312-d can offer marked neuronal protective effects against ischemic injury.
T34086	Platonin	NK 19
	Platonin is a therapeutic immunomodulating medicine and a possible medicine against ischemic stroke.
T31978	GM-608	GM-606,GM-607,GM-604,GM-603,GM-605,GM-602
	GM-604(alirinetide) is a potential treatment for amyotrophic lateral sclerosis and ischemic stroke.
T28438	2-(1-hydroxypentyl)benzoic Acid	dl-PHPB
	Potassium-Hydroxypentyl Benzoate is a drug potentially for the treatment of acute ischemic stroke (AIS)

Compounds

Colivelin

TP1856

Synonym:

Target: Beta Amyloid, STAT

Dilazep dihydrochloride

Synonym: Org25969,Sugammadex (sodium)

Target: GSK-3, S6 Kinase

Aplodan

T20843

Synonym: Nergize,Creatinolfosfate,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Synonym: MD-67350,Vasodistal,Brendil

Target: Calcium Channel

Nebivolol hydrochloride

T0154

Synonym: R 065824 hydrochloride,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Moexipril hydrochloride

T6595

Synonym: Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

YM-244769 dihydrochloride

T39195

Synonym:

Target: Calcium Channel

YM-244769

T9888

Synonym: 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Target: Calcium Channel

Annaosanchun

T19659

Synonym: YC6,YC-6,YC 6

Target: Others, AMPK

Afacifenacin

T29687

Synonym: Afacifenacin fumarate,SMP-986,NS 986,NS-986,SMP 986,NS986,SMP986

Target: AChR

Asundexian

T39463

Synonym: BAY 2433334,Asundexian,BAY2433334,BAY-2433334

Target: Factor Xa

Aptiganel

T26645

Synonym: CNS 1102,CNS-1102,CNS1102

Trimetazidine dihydrochloride

T0988

Synonym: Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Isbogrel

T27630

Synonym: CV4151,CV-4151,CV 4151

Target: Prostaglandin Receptor

Trapidil

T0080

Synonym: Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Synonym: LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730

Target: Platelet aggregation

GSK854

T24115

Synonym: GSK-854,GSK 854

Target: Others, iGluR

BRL 52537 hydrochloride

T21757

Synonym:

Target: Opioid Receptor

K201

T24239

Synonym: K-201,JTV 519,JTV-519,K 201

Target: Calcium Channel

Adatanserin hydrochloride

T29645

Synonym: WY50324 hydrochloride

Target: 5-HT Receptor

LFHP-1c

T78141

Synonym:

Target: Phospholipase

CA 074

T21509

Synonym:

Target: Cysteine Protease

Target: Sodium Channel

MMPSI

T21871

Synonym: Caspase-3/7 Inhibitor I

Target: Apoptosis, Caspase

Tat-NR2B9c

T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

Darexaban

T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

3-hydroxy-3-phenylpentanamide

Target: SARS-CoV, TRP/TRPV Channel

Sodium Hydrogen Sulfide (hydrate)

Synonym: R-59494,R59494

Target:

Lifarizine methanesulfonate

Synonym: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)olean-9(11)-en-29-oic acid

Target: Others

S-312-d

T28646

Synonym: S312-d,S 312-d,S-312d,S 312d

Synonym: GM-606,GM-607,GM-604,GM-603,GM-605,GM-602

Target:

2-(1-hydroxypentyl)benzoic Acid

T28438

Synonym: dl-PHPB

Target:

カタログ番号	製品名	別名	ターゲット
T19466	N8-Acetylspermidine dihydrochloride		Endogenous Metabolite
	N8-Acetylspermidine dihydrochloride is a polyamine.		Endogenous Metabolite
T6S1294	Nicotiflorin	Nictoflorin,Kaempferol-3-O-Rutinoside,Nicotifloroside	Others
	1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative s...		Others
T3871	Daucosterol	Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A	Glucosidase
	Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1...		Glucosidase
T6S1495	Ginsenoside Rk3		Others , NF-κB
	1. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. 2. Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases.		Others , NF-κB
T8074	Esafosfan trisodium	Fosfructose trisodium,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others , Endogenous Metabolite
	Esafosfan trisodium (FDP trisodium) is a cytoprotective natural sugar phosphate for the potential treatment of sickle cell anemia, cardiovascular ischemia and asthma. It acts by stimulating anaerobic glycolysis which gen...		Others , Endogenous Metabolite
T3752	4-Hydroxybenzyl alcohol	4-Methylolphenol,P-Methylolphenol	Apoptosis , Endogenous Metabolite
	4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe...		Apoptosis , Endogenous Metabolite
TN1956	Mulberrofuran G		Phosphatase , HBV , Glucosidase
	Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the...		Phosphatase , HBV , Glucosidase
T20793	Magnesium Lithospermate B	Monomethyl lithospermate B,Lithospermate B	Others
	Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is...		Others
T3228	Fosfructose	D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others , Endogenous Metabolite
	D-fructose-1,6-diphosphate (D-fructose-1,6-diphosphate), also known as Fosfructose, is a cytoprotective natural sugar phosphate. It functions by promoting anaerobic glycolysis, which generates adenosine triphosphate (ATP...		Others , Endogenous Metabolite
T6S0659	Rhynchophylline	Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel , NF-κB
	1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c...		Calcium Channel , NF-κB
T2S1008	Oxysophoridine	Sophoridine N-oxide	Apoptosis , Antioxidant
	Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ...		Apoptosis , Antioxidant
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T3S1553	Trans-Cinnamaldehyde	Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein	COX , Endogenous Metabolite
	1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...		COX , Endogenous Metabolite
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T3S2259	Methyl eugenol	4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether	GABA Receptor
	1. Methyl eugenol (4-allylveratrole) is a natural constituent of the essential oils of a number of plants widely used in foodstuffs as flavouring agents, in view of the carcinogenic potential of ME, the need to check its...		GABA Receptor
TN1412	Astringin	trans-Astringin	IL Receptor , Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be corre...		IL Receptor , Others
T4S0280	Eleutheroside D
	Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
TN3612	Caulophine		Others
	Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism.		Others
T74191	Tanshinol borneol ester
	Tanshinol borneol ester, an angiogenesis stimulator, enhances several critical phases of angiogenesis via the Akt and MAPK signaling pathways. This compound also exhibits anti-ischemic and anti-atherosclerosis properties...
T2S0118	Daurinoline		Calcium Channel , 5-HT Receptor , Histamine Receptor
	Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mat...		Calcium Channel , 5-HT Receptor , Histamine Receptor
TN5498	6,7,4'-Trihydroxyflavanone		Others
			Others
TN3323	Monomethyl lithospermate	Lithospermic acid monomethyl ester	Akt , PI3K
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) has potential antiviral activity, alleviating ischemic stroke injury in vivo in middle cerebral artery occlusion mice by activating PI5K/Akt signaling and pro...		Akt , PI3K
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR

天然物製品

N8-Acetylspermidine dihydrochloride

T19466

Synonym:

Target: Endogenous Metabolite

Nicotiflorin

T6S1294

Synonym: Nictoflorin,Kaempferol-3-O-Rutinoside,Nicotifloroside

Target: Others

Daucosterol

T3871

Synonym: Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A

Target: Others, NF-κB

Esafosfan trisodium

T8074

Synonym: Fosfructose trisodium,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Target: Others, Endogenous Metabolite

4-Hydroxybenzyl alcohol

T3752

Synonym: 4-Methylolphenol,P-Methylolphenol

Target: Apoptosis, Endogenous Metabolite

Mulberrofuran G

TN1956

Synonym:

Target: Phosphatase, HBV, Glucosidase

Magnesium Lithospermate B

T20793

Synonym: Monomethyl lithospermate B,Lithospermate B

Target: Others

Fosfructose

T3228

Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Target: Others, Endogenous Metabolite

Rhynchophylline

T6S0659

Synonym: Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Oxysophoridine

T2S1008

Synonym: Sophoridine N-oxide

Target: Apoptosis, Antioxidant

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

trans-Cinnamaldehyde

T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Methyl eugenol

T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether

Target: GABA Receptor

Astringin

TN1412

Synonym: trans-Astringin

Target: IL Receptor, Others

Tanshinol borneol ester

Target: Calcium Channel, 5-HT Receptor, Histamine Receptor

6,7,4'-Trihydroxyflavanone

TN5498

Synonym:

Target: Others

Monomethyl lithospermate

TN3323

Synonym: Lithospermic acid monomethyl ester

Target: IL Receptor, TNF, NOS, LTR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc)	Human	HEK293
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia...
TMPY-01883	EPOR Protein, Human, Recombinant (His)	Human	HEK293
	Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific ...
TMPY-02556	FSTL1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a mu...
TMPY-02927	RAGE Protein, Human, Recombinant (His)	Human	HEK293
	Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-02881	RAGE Protein, Human, Recombinant	Human	HEK293
	Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-03377	CD73 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-01851	CD73 Protein, Human, Recombinant (His)	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-01342	CD73 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-03540	CD73 Protein, Rat, Recombinant (His)	Rat	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-03577	Pleiotrophin/PTN Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, ...
TMPY-05053	ANGPTL2 Protein, Human, Recombinant (His)	Human	HEK293
	The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
TMPY-00344	ARL6IP6 Protein, Human, Recombinant (mFc)	Human	HEK293
	It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular ...
TMPJ-00681	EDIL3 Protein, Human, Recombinant (His)	Human	Human Cells
	EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at...
TMPJ-01257	PMM1 Protein, Human, Recombinant (His)	Human	E. coli
	Phosphomannomutase 1 (PMM1) blongs to the eukaryotic PMM family. Phosphomannomutase 1 can catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. G...
TMPY-06109	EPOR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific ...
TMPH-01634	MLYCD Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid syn...
TMPY-02298	ACYP2 Protein, Human, Recombinant (GST)	Human	E. coli
	Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to c...
TMPY-01224	EPOR Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific ...
TMPY-00794	EPOR Protein, Human, Recombinant (hFc)	Human	HEK293
	Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific ...
TMPY-00521	EPOR Protein, Mouse, Recombinant (hFc)	Mouse	Baculovirus-Insect Cells
	Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific ...
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPY-02239	FABP3 Protein, Human, Recombinant	Human	E. coli
	Fatty acid binding protein 3 (FABP3, also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport, cell growth, cellular s...
TMPY-05580	CD73 Protein, Human, Recombinant (hFc)	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-01106	FSTL1 Protein, Human, Recombinant (His)	Human	HEK293
	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a mu...
TMPY-00613	FSTL1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a mu...
TMPY-00410	EPHX2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the ...
TMPJ-00785	FABP3 Protein, Human, Recombinant (His)	Human	E. coli
	Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is in...
TMPY-01675	RAGE Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-01716	RAGE Protein, Human, Recombinant (hFc)	Human	HEK293
	Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai...
TMPY-05454	CD73 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-06907	CD73 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-03361	Pleiotrophin/PTN Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, ...
TMPY-00605	FABP3 Protein, Mouse, Recombinant	Mouse	E. coli
	Fatty acid binding protein 3 (FABP3, also termed heart-type fatty acid binding protein) is a member of the intracellular lipid-binding protein family that may be essential in fatty acid transport, cell growth, cellular s...
TMPY-02850	Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, ...
TMPY-01875	SCGN Protein, Human, Recombinant (His)	Human	E. coli
	Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high level...
TMPY-00028	ARMET/MANF Protein, Human, Recombinant (hFc)	Human	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-02732	ARMET/MANF Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-01678	ARMET/MANF Protein, Human, Recombinant (His)	Human	HEK293
	Mesencephalic astrocyte-derived neurotrophic factor, also known as Protein ARMET, Arginine-rich protein, MANF, and ARMET, is a secreted protein that belongs to the ARMET family. ARMET selectively promotes the survival of...
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His)	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...
TMPY-03998	ANGPTL2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...

Dermcidin Protein, Human, Recombinant (hFc)

TMPY-00545

Species: Human

Expression System: HEK293

EPOR Protein, Human, Recombinant (His)

TMPY-01883

Species: Human

Expression System: HEK293

FSTL1 Protein, Mouse, Recombinant (His)

TMPY-02556

Species: Mouse

Expression System: HEK293

RAGE Protein, Human, Recombinant (His)

TMPY-02927

Species: Human

Expression System: HEK293

RAGE Protein, Human, Recombinant

TMPY-02881

Species: Human

Expression System: HEK293

CD73 Protein, Cynomolgus, Recombinant (His)

TMPY-03377

Species: Cynomolgus

Expression System: HEK293

CD73 Protein, Human, Recombinant (His)

TMPY-01851

Species: Human

Expression System: HEK293

CD73 Protein, Mouse, Recombinant (His)

TMPY-01342

Species: Mouse

Expression System: HEK293

CD73 Protein, Rat, Recombinant (His)

TMPY-03540

Species: Rat

Expression System: HEK293

Pleiotrophin/PTN Protein, Mouse, Recombinant

TMPY-03577

Species: Mouse

Expression System: Baculovirus-Insect Cells

ANGPTL2 Protein, Human, Recombinant (His)

TMPY-05053

Species: Human

Expression System: HEK293

ARL6IP6 Protein, Human, Recombinant (mFc)

TMPY-00344

Species: Human

Expression System: HEK293

EDIL3 Protein, Human, Recombinant (His)

TMPJ-00681

Species: Human

Expression System: Human Cells

PMM1 Protein, Human, Recombinant (His)

TMPJ-01257

Species: Human

Expression System: E. coli

EPOR Protein, Human, Recombinant (His), Biotinylated

TMPY-06109

Species: Human

Expression System: HEK293

MLYCD Protein, Human, Recombinant (His & Myc)

TMPH-01634

Species: Human

Expression System: E. coli

ACYP2 Protein, Human, Recombinant (GST)

TMPY-02298

Species: Human

Expression System: E. coli

EPOR Protein, Mouse, Recombinant (His)

TMPY-01224

Species: Mouse

Expression System: HEK293

EPOR Protein, Human, Recombinant (hFc)

TMPY-00794

Species: Human

Expression System: HEK293

EPOR Protein, Mouse, Recombinant (hFc)

TMPY-00521

Species: Mouse

Expression System: Baculovirus-Insect Cells

BNIP3L Protein, Human, Recombinant

TMPY-02376

Species: Human

Expression System: E. coli

FABP3 Protein, Human, Recombinant

TMPY-02239

Species: Human

Expression System: E. coli

CD73 Protein, Human, Recombinant (hFc)

TMPY-05580

Species: Human

Expression System: HEK293

FSTL1 Protein, Human, Recombinant (His)

TMPY-01106

Species: Human

Expression System: HEK293

FSTL1 Protein, Mouse, Recombinant (hFc)

TMPY-00613

Species: Mouse

Expression System: HEK293

EPHX2 Protein, Human, Recombinant (His)

TMPY-00410

Species: Human

Expression System: Baculovirus-Insect Cells

FABP3 Protein, Human, Recombinant (His)

TMPJ-00785

Species: Human

Expression System: E. coli

RAGE Protein, Mouse, Recombinant (His)

TMPY-01675

Species: Mouse

Expression System: HEK293

RAGE Protein, Human, Recombinant (hFc)

TMPY-01716

Species: Human

Expression System: HEK293

CD73 Protein, Human, Recombinant (His), Biotinylated

TMPY-05454

Species: Human

Expression System: HEK293

CD73 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06907

Species: Human

Expression System: HEK293

Pleiotrophin/PTN Protein, Human, Recombinant

TMPY-03361

Species: Human

Expression System: Baculovirus-Insect Cells

FABP3 Protein, Mouse, Recombinant

TMPY-00605

Species: Mouse

Expression System: E. coli

Pleiotrophin/PTN Protein, Mouse, Recombinant (hFc)

TMPY-02850

Species: Mouse

Expression System: HEK293

SCGN Protein, Human, Recombinant (His)

TMPY-01875

Species: Human

Expression System: E. coli

ARMET/MANF Protein, Human, Recombinant (hFc)

TMPY-00028

Species: Human

Expression System: HEK293

ARMET/MANF Protein, Mouse, Recombinant (His)

TMPY-02732

Species: Mouse

Expression System: HEK293

ARMET/MANF Protein, Human, Recombinant (His)

TMPY-01678

Species: Human

Expression System: HEK293

HIF-1 alpha Protein, Human, Recombinant (His)

TMPY-01709

Species: Human

Expression System: E. coli

ANGPTL2 Protein, Mouse, Recombinant (hFc)

TMPY-03998

Species: Mouse

Expression System: HEK293

カタログ番号	製品名
L5400	Anti-Cardiovascular Disease Compound Library	1408 compounds
	A unique collection of 1408 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS);
L4800	Angiogenesis related Compound Library	1353 compounds
	A unique collection of 1353 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
L8500	HIF-1 Signaling Pathway Compound Library	1336 compounds
	A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；

ライブラリー

Anti-Cardiovascular Disease Compound Library

L5400

Compounds: 1408

Angiogenesis related Compound Library

L4800

Compounds: 1353

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1336