Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum.
説明 | Cipargamin (NITD609) is an effective antimalarial compound. It has an IC50 of appr 1 nM against P. falciparum. |
ターゲット&IC50 | P. falciparum:1 nM |
In vitro | Cipargamin is the most effective inhibitor of early gametocyte development at 50 and 500 nM. Cipargamin displays a dose-dependent inhibiting effect on late gametocyte development. Cipargamin inhibits T. gondii with an MIC90 for tachyzoites of 5 μM and an MIC50 of 1 μM. At the highest concentration tested (10 μM), It has no toxicity to human foreskin fibroblasts (HFFs). Cipargamin shows effective activities against a panel of culture-adapted P. falciparum strains (IC50: 0.5-1.4 nM). Cipargamin is effective as an artesunate with potency in the low nanomolar range (ICIC50 values consistently <10 nM) against all P. falciparum and P. vivax isolates [1][2][3]. |
In vivo | Cipargamin (100 mg/kg) fully clears P. berghei infection in all treated mice, and partial cure (50%) is achieved with a single oral dose at 30 mg/kg. Cipargamin displays favorable pharmacokinetic properties and shows single-dose cure efficacy in a malaria mouse model [3]. |
別名 | KAE609, NITD609 |
分子量 | 390.24 |
分子式 | C19H14Cl2FN3O |
CAS No. | 1193314-23-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 55 mg/mL (140.94 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Cipargamin 1193314-23-6 Microbiology/Virology Parasite inhibit KAE609 KAE-609 NITD-609 NITD 609 Inhibitor NITD609 KAE 609 inhibitor