|
T14981 |
Clobetasone butyrate
|
|
Glucocorticoid Receptor
|
|
Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis... |
|
T2548 |
Diflorasone
|
|
Glucocorticoid Receptor
|
|
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorti... |
|
T3481 |
Bimolane
|
|
Topoisomerase
|
|
Bimolane is a topoisomerase II inhibitor. |
|
T16832 |
S18-000003
|
|
ROR
|
|
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. |
|
T9635 |
Cedirogant
|
ABBV-157 |
ROR
|
|
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study. |
|
T17038 |
Tepilamide fumarate
|
XP-23829 |
Others
|
|
Tepilamide fumarate (XP-23829) is an oral fumaric acid ester and is used in the research of moderate to severe chronic plaque psoriasis. |
|
T14369 |
AZD-0284
|
|
ROR
|
|
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. |
|
T12399 |
Peldesine
|
BCX 34 |
Nucleoside Antimetabolite/Analog
,
HIV Protease
|
|
|
|
T4050 |
GSK2981278
|
ROR gama modulator 1 |
ROR
|
|
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
|
T1561 |
Clobetasol propionate
|
Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725 |
Glucocorticoid Receptor
,
P450
|
|
Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain a... |
|
T68006 |
Orilotimod potassium
|
APO805K1 |
|
|
Orilotimod potassium (APO805K1) can be used to study plaque psoriasis. |
|
T76784 |
Tildrakizumab
|
MK 3222,SCH 900222 |
IL Receptor
|
|
Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and ps... |
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T76778 |
Risankizumab
|
Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066 |
IL Receptor
|
|
Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.R... |
|
T38105 |
Ixekizumab
|
LY2439821 |
IL Receptor
,
Interleukin
|
|
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 ... |
|
T76779 |
Brodalumab
|
LP 0160,KHK-4827,AMG-827 |
IL Receptor
|
|
Brodalumab (AMG 827) is a human monoclonal antibody targeting interleukin 17 receptor (IL-17R) IgG2, often used as an immunosuppressant in the treatment of psoriasis and psoriasis. |
|
T28698 |
SC-22716
|
SC 22716,SC22716 |
Aminopeptidase
|
|
SC-22716 is an orally active leukotriene A4 (LTA4) hydrolase inhibitor.SC-22716 has potential anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis. |
|
T13911 |
Tacalcitol monohydrate
|
Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate |
Cysteine Protease
|
|
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis. |
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T67943 |
RORγ inverse agonist 1
|
|
|
|
RORγ inverse agonist 1 has anti-inflammatory activity and can be used to treat rheumatism and psoriasis. |
|
T2018 |
Apilimod
|
STA 5326 |
IL Receptor
,
PI3K
,
Interleukin
|
|
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis. |
|
T83624 |
Selenium sulfide
|
|
Antibiotic
|
|
Selenium sulfide has antimicrobial activity and is commonly used to control dandruff, seborrheic dermatitis and psoriasis. |
|
T37445 |
Etanercept
|
|
TNF
|
|
Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TN... |
|
T25393 |
Etarotene
|
RO15-1570,Arotinoid ethyl sulphone,RO-15-1570,RO 15-1570 |
Tyrosinase
|
|
Etarotene (Arotinoid ethyl sulphone) is an ethylsulfonyl derivative of aloe acid with differentiation-inducing and potentially antitumor activity.Etarotene is a collagenase inhibitor and can be used to study psoriasis. |
|
T80800 |
WAY-616296
|
|
Others
|
|
WAY-616296 has potential anticholesterol activity and can be used in the study of diabetes, hypertension, psoriasis and obesity. |
|
T4644 |
Tapinarof
|
GSK2894512,Benvitimod,WBI 1001 |
AhR
,
Aryl Hydrocarbon Receptor
|
|
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease. |
|
T76747 |
Fletikumab
|
Anti-IL-20,NN-8226,NNC 0109-0012 |
Interleukin
|
|
Fletikumab (NNC0109-0012) is a monoclonal antibody against IL-20 that is often used as an IL-20 inhibitor.Fletikumab is used in the study of rheumatoid arthritis and psoriasis. |
|
T3620 |
Solcitinib
|
GLPG-0778,GSK-2586184 |
JAK
|
|
Solcitinib (GLPG-0778) (GSK2586184, GLPG0778) is a JAK1 inhibitor. Solcitinib may be potentially used for the treatment of psoriasis, ulcerative colitis, and systemic lupus erythematosus. |
|
T77751 |
Imaprelimab
|
PRX-003 |
Others
|
|
Imaprelimab (PRX-003) is a humanized IgG1 κmonoclonal antibody against melanoma cell adhesion molecule (MCAM). Imaprelimab has antitumor activity and can be used to study inflammation, tumors, and psoriasis. |
|
T24755 |
Salnacedin
|
G-201,SCY,G-201,G201,SCY,G 201 |
Others
|
|
Salnacedin (G-201) is a small molecule compound used in the treatment of immune system disorders, skin and musculoskeletal disorders, and can be used in studies of acne vulgaris, dermatitis and psoriasis. |
|
TQ0244 |
Calcipotriol monohydrate
|
|
|
|
|
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T71461 |
CPG-52364
|
CPG52364,CPG 52364 |
Others
|
|
CPG-52364 is a small molecule compound that interacts between an endosomal TLR and its ligand and is a candidate for the treatment of psoriasis. |
|
T7188 |
Piclidenoson
|
CF-101,IB-MECA |
Apoptosis
,
Adenosine Receptor
|
|
Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients. |
|
T25130 |
Azaribine
|
2',3',5'-Tri-O-acetyl-6-azauridine,NSC 67239 |
Antiviral
|
|
Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) is an orotate monophosphate decarboxylase (OMPD) inhibitor with broad-spectrum antiviral activity, inhibiting viral genome replication and gene transcription.Azaribine has b... |
|
T77685 |
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
|
|
PDK
|
|
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study angiosarcoma, adenocarcinoma, multiple myeloma, psoriasis, prostate can... |
|
T6696 |
Tazarotene
|
Tazorac,AGN 190168,Zorac |
Retinoid Receptor
,
Autophagy
|
|
Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati... |
|
T60052 |
BMS-905
|
|
TLR
|
|
BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatment of diseases such as psoriasis, arthritis, and lupus. |
|
T77170 |
Siplizumab
|
MEDI-507 |
Others
|
|
Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody targeting CD2. Siplizumab selectively depletes effector memory T cells and promotes relative expansion of alloreactive regulatory T cells in vitro. Siplizumab... |
|
T75113 |
GLPG2534
|
GLPG-2534 |
IRAK
|
|
GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis. |
|
T68108L |
Moxilubant HCl
|
Moxilubant hcl(146978-48-5 Free base) |
LTR
|
|
Moxilubant HCl is a small molecule leukotriene B4 receptor 1 (LTB4R) antagonist for the treatment of immune system disorders, skin and musculoskeletal disorders, and may be used in studies of psoriasis and rheumatoid art... |
|
T73578 |
JY-2
|
|
FOXO1
|
|
JY-2 is an orally active and selective forkhead transcription factor O1 (FoxO1) inhibitor with antidiabetic activity and inhibits FoxO1 transcription.JY-2 can be used to study psoriasis and diabetes. |
|
T9930 |
Secukinumab
|
|
IL Receptor
|
|
Secukinumab is a fully humanized monoclonal anti-IL-17A antibody and the first in its class to be approved by the US Food and Drug Administration for the treatment of moderate to severe plaque psoriasis. |
|
T76775 |
Fezakinumab
|
ILV 094 |
Interleukin
|
|
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat... |
|
T77491 |
Prezalumab
|
AMG 557 |
Others
|
|
Prezalumab (AMG 557) is a human IgG2 monoclonal antibody against ICOSL and BAFF. Prezalumab can be used to study sjogren's syndrome cutaneous lupus erythematosus, psoriasis, systemic lupus erythematosus arthritis and sys... |
|
T7370 |
Talarozole
|
R115866 |
Others
,
P450
,
Retinoid Receptor
,
Autophagy
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of... |
|
T0339 |
Resorcinol monoacetate
|
Resorcin monoacetate |
Others
|
|
Resorcinol monoacetate (Resorcin monoacetate) is an antiseptic and a disinfectant, is a chemical intermediate for the production of many other pharmaceuticals, and can be used to treat acne, seborrheic dermatitis, eczema... |
|
T0500 |
Chloroxine
|
Capitrol |
Antibacterial
,
Antibiotic
|
|
Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epi... |
|
T6831 |
Etretinate
|
Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359 |
Apoptosis
,
Others
|
|
Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c... |
|
T37379 |
Protectin D1
|
Neuroprotectin D1,NPD1 |
Akt
,
PI3K
|
|
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psor... |
|
T76781 |
Itolizumab
|
EQ-001 |
Others
|
|
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the producti... |
|
T76924 |
Efalizumab
|
Hu1124,HU 1124 |
Integrin
|
|
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinoc... |
|
T77600 |
Methyl-4-oxoretinoate
|
|
Apoptosis
|
|
Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other ... |
