Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 32,500 | |||
5 mg | 在庫あり | ¥ 78,000 | |||
10 mg | 在庫あり | ¥ 117,000 | |||
25 mg | 在庫あり | ¥ 190,000 | |||
50 mg | 在庫あり | ¥ 264,000 | |||
100 mg | 在庫あり | ¥ 356,000 | |||
500 mg | 在庫あり | ¥ 682,000 |
説明 | DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels. |
In vivo | In the normal ICR mice, DA-6886 (0.4 and 2mg/kg; oral) resulted in a marked stimulation of colonic transit. In the loperamide-induced constipation mouse model, DA-6886 (2mg/kg) significantly improved the delay of colonic transit. Taken together, DA-6886 is a highly potent and selective 5-HT4 receptor agonist to accelerate colonic transit in mice, which might be a therapeutic agent having a favorable safety profile in the treatment of gastrointestinal motor disorders such as IBS-C and chronic constipation.[1] |
別名 | DA6886, DA 6886 |
分子量 | 443.37 |
分子式 | C19H28Cl2N6O2 |
CAS No. | 1645260-76-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (101.5 mM)
You can also refer to dose conversion for different animals. 詳細
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DA-6886 1645260-76-9 GPCR/G Protein Neuroscience 5-HT Receptor DA6886 DA 6886 Inhibitor inhibitor inhibit