Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM).
説明 | LY2940094 (LY-2940094) decreases ethanol self-administration in animal models. LY2940094 is an effective, selective, and orally available nociceptin receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). |
ターゲット&IC50 | NOP receptor: 0.166 nM(Kb), NOP receptor:(ki)0.105 nM |
In vivo | In Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, LY-2940094 (3, 10, or 30 mg/kg; 2-3 mL/kg; orally daily; for 4 days) dose-dependently decreases homecage ethanol self-administration, without affecting food/water intake or locomotor activity. |
別名 | LY-2940094 |
分子量 | 480.96 |
分子式 | C22H23ClF2N4O2S |
CAS No. | 1307245-86-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.67 mg/mL (86.64 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LY2940094 1307245-86-8 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor depressive orally ethanol self-administration LY-2940094 Inhibitor brain BTRX 246040 inhibit penetrate BTRX-246040 BTRX246040 major LY 2940094 disorder inhibitor