keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 35,500 | |||
25 mg | 在庫あり | ¥ 68,500 | |||
50 mg | 在庫あり | ¥ 102,000 | |||
100 mg | 在庫あり | ¥ 147,000 |
説明 | DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities. |
ターゲット&IC50 | Gp120CM CM235/sCD4-CCR5:0.32 nM (IC50, in Cf2Th/synR5 cells), Gp120 BaL/sCD4-CCR5:55 pM (IC50, in Cf2Th/synR5 cells) |
In vitro | D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1] |
別名 | DAPTA(TFA), D-Ala-peptide T-amide, Adaptavir |
分子量 | 856.88 |
分子式 | C35H56N10O15 |
CAS No. | 106362-34-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10mM
You can also refer to dose conversion for different animals. 詳細
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DAPTA 106362-34-9 Immunology/Inflammation Microbiology/Virology Proteases/Proteasome HIV Protease CCR HIV DAPTA(TFA) CC chemokine receptor Human immunodeficiency virus D-Ala-peptide T-amide inhibit Adaptavir Inhibitor inhibitor