Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DB07268 is a potent and selective JNK1 inhibitor.
説明 | DB07268 is a potent and selective JNK1 inhibitor. |
ターゲット&IC50 | JNK1:9 nM. |
キナーゼ試験 | Following 3T3L1 adipocyte serum-starvation and insulin stimulation, cell lysates containing protease inhibitors are clarified and then subjected to immunoprecipitation with anti-PIKfyve antibodies. Washed beads are mixed with 100 μM PtdIns and preincubated for 15 min with YM-201636 (100 nM) or vehicle in the assay buffer (50 mM Tris-HCl, pH 7.5, 1 mM EGTA and 10 mM MgCl2). The kinase assay (50 μL final volume) is carried out for 15 min at 37 °C with 15 μM ATP and [γ-32P]ATP (30 μCi). Lipids are extracted, spotted on TLC glass plates (250 μm), resolved by a chloroform/methanol/water/ammonia solvent system and detected by autoradiography[2]. |
分子量 | 321.33 |
分子式 | C17H15N5O2 |
CAS No. | 929007-72-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (155.6 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DB07268 929007-72-7 MAPK JNK DB 07268 DB-07268 Inhibitor inhibit inhibitor