Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A).
説明 | DJ-V-159 is a GPRC6A agonist, targeting the G protein-coupled receptor family C group 6 member A (GPRC6A). |
In vitro | DJ-V159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A [1]. |
In vivo | DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice at 60 and 90 minutes, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 (10 mg/kg, i.p.) reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five [1]. |
別名 | DJ-V159 |
分子量 | 502.37 |
分子式 | C24H12F6N4O2 |
CAS No. | 2253744-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.02 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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DJ-V-159 2253744-53-3 Endocrinology/Hormones GPCR/G Protein Androgen Receptor GPR DJV159 Inhibitor inhibit DJ-V159 DJ V 159 DJ-V 159 inhibitor