Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,500 | |||
25 mg | 在庫あり | ¥ 19,000 | |||
50 mg | 在庫あり | ¥ 31,000 | |||
100 mg | 在庫あり | ¥ 55,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
ターゲット&IC50 | GPR120:5.46(pEC50), FFA1/GPR40:7.32(pEC50) |
In vivo | In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10. |
別名 | GW 9508 |
分子量 | 347.41 |
分子式 | C22H21NO3 |
CAS No. | 885101-89-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 34.7 mg/mL (100 mM)
DMSO: 34.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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GW9508 885101-89-3 Endocrinology/Hormones GPCR/G Protein Membrane transporter/Ion channel GPR Potassium Channel TNF-α KcsA insulin GPR40 glucose-sensitive GPR120 Free Fatty Acid Receptor KATP FFA1 anti-inflammatory CCL5 CXCL10 Inhibitor inhibit GW-9508 IFN-γ GW 9508 FFAR anti-atherosclerotic inhibitor