Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,500 | |||
2 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 19,500 | |||
10 mg | 在庫あり | ¥ 33,000 | |||
25 mg | 在庫あり | ¥ 65,000 | |||
50 mg | 在庫あり | ¥ 109,500 | |||
100 mg | 在庫あり | ¥ 160,500 | |||
500 mg | 在庫あり | ¥ 337,500 |
説明 | Dabigatran (BIBR 953ZW) is a THROMBIN inhibitor which acts by binding and blocking thrombogenic activity and the prevention of thrombus formation. It is used to reduce the risk of stroke and systemic EMBOLISM in patients with nonvalvular atrial fibrillation. |
ターゲット&IC50 | Thrombin:9.3 nM |
In vitro | BIBR 953 is a very potent anticoagulant. BIBR 953 shows that the terminal phenyl can be substituted by the more hydrophilic 2-pyridyl group without substantial loss of activity. BIBR 953 inhibits thrombin, plasmin, factor Xa, trypsin, tPA and activated protein C with Ki of 4.5 nM, 1.7 μM, 3.8 μM, 50 nM, 45 μM and 20 μM, respectively. [1] BIBR 953 specifically and reversibly inhibits thrombin. [2] |
In vivo | BIBR 953 exhibits the most favorable activity profile following i.v. administration to rats. [1] The bioavailability of dabigatran after p.o. administration of dabigatran etexilate is 7.2%. Dabigatran is predominantly excreted in the feces after p.o. treatment and in the urine after i.v. treatment. The mean terminal half-life of dabigatran is approximately 8 hours. Dabigatran acylglucuronides accounts for 0.4% and 4% of the dose in urine after p.o. and i.v. dosing, respectively. [3] |
別名 | BIBR 953, BIBR 953ZW |
分子量 | 471.51 |
分子式 | C25H25N7O3 |
CAS No. | 211914-51-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M HCL: 12.5 mg/mL (26.51 mM), Sonication is recommended.
DMSO: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 0.1 mg/mL (insoluble)
You can also refer to dose conversion for different animals. 詳細
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Dabigatran 211914-51-1 Proteases/Proteasome Thrombin Inhibitor BIBR 953 inhibit BIBR 953ZW BIBR953 BIBR-953 inhibitor