Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
説明 | 1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP. |
ターゲット&IC50 | Platelet:34.914 ug/mL |
植物由来 |
別名 | Dehydrocorydalin, 13-Methylpalmatine |
分子量 | 366.43 |
分子式 | C22H24NO4 |
CAS No. | 30045-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 66 mg/mL(180.1 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
You can also refer to dose conversion for different animals. 詳細
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Dehydrocorydaline 30045-16-0 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair MAPK Microbiology/Virology Proteases/Proteasome Caspase BCL p38 MAPK PARP Parasite Dehydrocorydalin Bcl-2 Family inhibit Inhibitor 13-Methylpalmatine poly ADP ribose polymerase inhibitor