Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.
説明 | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
In vitro |
Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.? |
In vivo |
A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.?Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
植物由来 |
別名 | 6,7,4'-Trihydroxyisoflavone |
分子量 | 270.24 |
分子式 | C15H10O5 |
CAS No. | 17817-31-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (462.55 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Desmethylglycitein 17817-31-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling PI3K/Akt/mTOR signaling PKC PI3K CDK Inhibitor 4',6,7-Trihydroxyisoflavone Phosphoinositide 3-kinase Cyclin dependent kinase inhibit 6,7,4'-Trihydroxyisoflavone Protein kinase C inhibitor