Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 56,000 | |||
50 mg | 在庫あり | ¥ 93,000 | |||
100 mg | 在庫あり | ¥ 135,500 | |||
500 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 15,000 |
説明 | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. |
ターゲット&IC50 | FLAP:20 nM, Others:20 nM |
In vitro | Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM). |
In vivo | Diflapolin (1-10 mg/kg; i.p.; 30?min before zymosan injection) exhibits potent anti-inflammatory properties in in-vivo experiments |
分子量 | 458.36 |
分子式 | C22H17Cl2N3O2S |
CAS No. | 724453-98-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 84mg/mL (183.26mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Diflapolin 724453-98-9 Immunology/Inflammation Metabolism Others FLAP Epoxide Hydrolase diseases Inhibitor permeability neutrophil vascular infiltration 5-LO activating protein inflammation cysteinyl-LTs inhibit inhibitor