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T8844 |
Diflapolin
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Others
,
FLAP
,
Epoxide Hydrolase
|
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Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. |
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T8313 |
HCH6-1
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Others
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HCH6-1 is a competitive Formyl peptide receptor 1 (FPR1) antagonist. |
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T9043 |
AS1810722
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P450
,
STAT
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AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f... |
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T1115 |
Doxylamine succinate
|
Decapryn |
Histamine Receptor
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Doxylamine Succinate is a pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate (Decapryn) competitively blocks the histamine H1 receptor and limits the typical allergic and ... |
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T0946 |
Mepivacaine hydrochloride
|
Mepivacaine HCl |
Sodium Channel
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|
Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. |
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T2018 |
Apilimod
|
STA 5326 |
IL Receptor
,
PI3K
,
Interleukin
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|
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis. |
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T35367 |
Thioacetamide
|
TAA |
Others
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|
Thioacetamide is a hepatotoxicant used widely to induce experimental liver lesions, develops hepatocellular necrosis and subsequent inflammation (mainly M1-/M2-macrophages without neutrophil infiltration) in rats. |
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T8857 |
LJP-1586 HCl
|
LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586 |
Others
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|
LJP-1586 HCl, a highly selective inhibitor of vascular adhesion protein-1 (VAP-1), exhibits antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage (IC... |
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T1787 |
Levobupivacaine
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|
Sodium Channel
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|
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... |
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T0029 |
Procaine
|
Duracaine,Spinocaine,Novocaine,Vitamin H3 |
Histone Demethylase
,
DNA/RNA Synthesis
,
Sodium Channel
|
|
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. |
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T16379 |
Oglemilast
|
GRC 3886 |
PDE
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Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 0.5 nM ... |
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T6831 |
Etretinate
|
Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359 |
Apoptosis
,
Others
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|
Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c... |
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T8732 |
CTPI-2
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Others
,
Mitochondrial Metabolism
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CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha... |
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T61356 |
CXCR2 antagonist 3
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|
|
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CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar po... |
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TP1379 |
KKI-5 TFA(97145-43-2 free base)
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KKI-5 (TFA) |
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KKI-5 (TFA) is a specific tissue kallikrein inhibitor.Kki-5 (TFA) can reduce breast cancer cell infiltration. |
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T25525 |
IDT
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|
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IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model. |
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T70107 |
Olcorolimus
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|
|
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Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5 |
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T70874 |
Vipoglanstat
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|
|
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Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury. |
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T33595 |
Naproxcinod
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AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582 |
|
|
Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in... |
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T30215 |
AUY-954 free base
|
AUY 954,NVP-AUY954,AUY-954,AUY954 |
|
|
AUY-954 is an effective selective S1P(1) modulator. It can significantly reduce the local expression of EAN rat sciatic nerve T cells, B cells, macrophage infiltration, inflammatory demyelination, interleukin-17 and matr... |
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T40958 |
Milategrast
|
E6007 |
|
|
Milategrast is a chemical compound that functions as a potent cell adhesion inhibitor and cell infiltration inhibitor. In vitro studies have demonstrated its ability to effectively inhibit the adhesion of Jurkat cells to... |
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T76567 |
Met-RANTES (human)
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|
|
|
Met-RANTES (human), a partial antagonist of CCR5, diminishes the infiltration of blood monocytes into the liver [1]. |
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T37259 |
14(S)-HDHA
|
|
|
|
Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and... |
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T28933 |
TCV-309
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TCV309 |
|
|
TCV-309 is an inhibitor of platelet activating factor (PAF). TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. TCV-309 attenuates the priming eff... |
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T82642 |
Cyclo(RGDfK(Mal))
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|
|
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Cyclo(RGDfK(Mal)), a pentapeptide, enhances the attachment and infiltration of human pluripotent stem cells and is utilized in three-dimensional stem cell culture and expansion [1]. |
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T80502 |
P4pal10
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|
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P4pal10, a PAR 4 antagonist, inhibits thrombin-mediated aggregation of mouse platelets in vivo and significantly diminishes Carrageenan-induced edema and granulocyte infiltration [1]. |
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T61599 |
XT2
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|
|
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XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, in... |
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T79185 |
STAT6-IN-2
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|
STAT
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STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltration. This compound is useful in the study of immune diseases... |
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T38042 |
Resolvin D4
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Resolvin D4,RvD4 |
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Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreat... |
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T77163 |
Pexelizumab
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|
|
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Pexelizumab (h5G1.1-SC), a humanized scFv monoclonal antibody, targets the C5 complement component, thereby inhibiting apoptosis and leukocyte infiltration. It is utilized in researching cerebral ischemia-reperfusion (IR... |
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T76983 |
Tengonermin
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|
|
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Tengonermin (ARENEGYR), a vascular-targeting compound, comprises human Tumour Necrosis Factor-α (TNF-α) conjugated with the CNGRCG peptide. It enhances intratumoral chemotherapy delivery and T-cell infiltration by alteri... |
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T38043 |
Resolvin E4
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|
|
|
Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE inte... |
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T62927 |
HPK1-IN-22
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|
|
|
HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine... |
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T72668 |
PD-1/PD-L1-IN-26
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|
PD-1/PD-L1
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|
PD-1/PD-L1-IN-26 (Compound II-14) is a potent PD-1/PD-L1 inhibitor, demonstrating an IC50 of 0.0380 μM. It enhances the immune microenvironment by facilitating CD4+ T cell infiltration into tumor tissues, indicating pote... |
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T38384 |
Nexinhib20
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|
|
|
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony... |
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T62301 |
J-1063
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|
|
|
J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM). J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has poten... |
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T70346 |
TOP1362
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|
|
|
TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, bloc... |
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T76786 |
Cabiralizumab
|
|
|
|
Cabiralizumab (FPA 008), an anti-CSF1R monoclonal antibody (MAb), promotes T cell infiltration and boosts antitumor immune responses. It also prevents osteoclast activation, thereby inhibiting bone destruction, and is ut... |
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T71329 |
Theophylline-d6
|
|
|
|
Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist... |
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T79643 |
PD-1/PD-L1-IN-33
|
|
PD-1/PD-L1
|
|
PD-1/PD-L1-IN-33 (Compound N11), a PD-1/PD-L1 inhibitor, effectively impedes the interaction between PD-1 and PD-L1 with an IC50 of 6.3 nM. By doing so, it enhances T-cell proliferation, activation, and infiltration with... |
|
T73520 |
TNG260
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|
|
|
TNG260 is a CoREST-selective deacetylase ( CoreDAC ) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3 . TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 d... |
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T72145 |
Montelukast dicyclohexylamine
|
MK0476 dicyclohexylamine |
|
|
Montelukast dicyclohexylamine (MK0476), a potent, selective, and orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLT1), is utilized in the research of asthma, liver injury, and COVID-19. It exhibits a... |
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T38350 |
TAS 205
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|
|
|
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS ... |
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T37506 |
MCTR2
|
MCTR2 |
|
|
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is ... |
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T37503 |
Maresin 2
|
3R,14S-diHDHA |
|
|
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human mac... |
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T69230 |
AZD-1236
|
|
|
|
AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. ... |
|
T74393 |
Antitumor agent-36
|
|
|
|
Antitumor agent-36 exhibits strong anti-proliferative and anti-metastasis capabilities, causing significant DNA damage that results in elevated levels of γ-H2AX and p53. It promotes tumor cell apoptosis via the mitochond... |
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T62284 |
Anti-inflammatory agent 21
|
|
|
|
Anti-inflammatory agent 21 (compound 9o) is a low cytotoxic, orally active anti-inflammatory agent that acts on NO (IC50: 0.76 μM). Anti-inflammatory agent 21 is able to accumulate ROS and block NF-κB/MAPK signaling path... |
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T77090 |
Mitazalimab
|
|
|
|
Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that exhibits directed activity against tumors. By activating antigen-presenting cells, such as dendritic cells (DC), it triggers the initiation of t... |
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T37505 |
MCTR1
|
MCTR1 |
|
|
Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is ... |
