Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
説明 | ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM). |
ターゲット&IC50 | mPTP:2.8 μM |
In vitro | ER-000444793 is a small molecule and non-toxic mPTP inhibitor. It also has a mechanism of action independent of CypD inhibition. Both CsA and SfA dose-dependently reduce HTRF signal, showing the displacement of labeled CsA from rhCypD protein (CsA IC50=23?nM and SfA IC50=?5?nM). However, ER-000444793 has no effect up to a concentration of 50?μM, showing be short of displacement of labelled-CsA from rhCypD protein. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. These data display the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition[1]. |
分子量 | 354.4 |
分子式 | C23H18N2O2 |
CAS No. | 792957-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (141.08 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ER-000444793 792957-74-5 Metabolism Others Mitochondrial Metabolism Inhibitor inhibit ER000444793 ER 000444793 inhibitor