Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 13,000 | |||
10 mg | 在庫あり | ¥ 20,500 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 73,500 | |||
100 mg | 在庫あり | ¥ 111,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively. |
ターゲット&IC50 | EPAC1:3.2 μM, EPAC2:1.4 μM |
In vitro | In WT C57BL/6 mice, ESI-09 (10 mg/kg/d, i.p.) prevents SFG Rickettsiosis by inhibiting EPAC1. |
In vivo | ESI-09 specifically inhibits intracellular EPAC-mediated activation of Rap1 and phosphorylation of Akt, as well as EPAC-mediated secretion in pancreatic β-cells. In pancreatic cancer cells induced by 007-AM, ESI-09 reduces cell adhesion and inhibits cell migration. In Schwann cells stimulated by CPT-cAMP, ESI-09 significantly suppresses cell differentiation and myelination. Additionally, in SC neuronal cultures, ESI-09 notably decreases the number of O1-positive and MBP-positive cells. |
分子量 | 330.77 |
分子式 | C16H15ClN4O2 |
CAS No. | 263707-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.1 mg/mL (100 mM)
Ethanol: 6.6 mg/mL (20 mM)
You can also refer to dose conversion for different animals. 詳細
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ESI-09 263707-16-0 GPCR/G Protein Microbiology/Virology cAMP Virus Protease inhibit ESI 09 ESI09 Inhibitor inhibitor