Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 28,000 | |||
5 mg | 在庫あり | ¥ 57,500 | |||
10 mg | 在庫あり | ¥ 91,000 | |||
25 mg | 在庫あり | ¥ 153,000 | |||
50 mg | 在庫あり | ¥ 217,500 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 67,500 |
説明 | Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) is an orally available selective estrogen receptor degrader with IC50s of 48 for ERα and 870 nM for ERβ, respectively. |
ターゲット&IC50 | ERβ:870 nM , ERα:48 nM |
In vitro | Elacestrant exhibits inhibition of ERα expression in a dose-dependent manner, with an EC50 of 0.6 nM.?Treatment of ER-positive MCF-7 cells with E2 results in a potent and dose-dependent increase in proliferation, with an EC50 of 4 pM.?Treatment of cells with Elacestrant in the presence of 10 pM E2 results in a dose-dependent decrease in proliferation, with an IC50 value of 4.2 nM. Elacestrant selectively binds to and degrades the ER and is a potent antagonist of ER-positive breast cancer cell proliferation[1].? |
In vivo | In MCF-7 xenograft models, Elacestrant-treated animals survived longer than those treated with either control or ICI 182780. RAD1901 preserves ovariectomy-induced bone loss and prevents the uterotropic effects of E2. Elacestrant produces a robust and profound inhibition of tumor growth in MCF-7 xenograft models[1].? |
別名 | RAD1901 dihydrochloride |
分子量 | 531.56 |
分子式 | C30H40Cl2N2O2 |
CAS No. | 1349723-93-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (150.50 mM), Sonication is recommended.
H2O: 40 mg/mL (75.25 mM)
You can also refer to dose conversion for different animals. 詳細
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Elacestrant dihydrochloride 1349723-93-8 Endocrinology/Hormones Estrogen/progestogen Receptor inhibit RAD-1901 Dihydrochloride Inhibitor Elacestrant Dihydrochloride RAD1901 Dihydrochloride Estrogen Receptor/ERR Elacestrant RAD 1901 Dihydrochloride RAD1901 RAD 1901 RAD-1901 RAD1901 dihydrochloride inhibitor