Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
説明 | Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment. |
ターゲット&IC50 | Factor prolyl hydroxylase:(EC50)0.22 μM |
In vitro | Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition. |
In vivo | Enarodustat (1 and 3 mg/kg, p.o., in rats) treatment increases hemoglobin levels in a dose-dependent manner. |
別名 | JTZ-951 |
分子量 | 340.33 |
分子式 | C17H16N4O4 |
CAS No. | 1262132-81-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (244.85 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Enarodustat 1262132-81-9 Chromatin/Epigenetic Metabolism Others HIF/HIF Prolyl-Hydroxylase HIFs inhibit HIF-PH Hypoxia-inducible factors JTZ951 JTZ-951 JTZ 951 Inhibitor inhibitor