Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 22,000 | |||
10 mg | 在庫あり | ¥ 40,000 | |||
25 mg | 在庫あり | ¥ 77,500 | |||
50 mg | 在庫あり | ¥ 135,500 | |||
100 mg | 在庫あり | ¥ 186,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity. |
ターゲット&IC50 | EGFR:3 nM |
In vitro | Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50: 3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM) [1]. Falnidamol demonstrates antiproliferative activity in mitogenic assays performed with KB cells [2]. |
In vivo | Falnidamol (p.o.; 10 mg/kg/day; 16 days) completely suppressed tumor growth of human A431 xenografts with respective a T/C value of 15% after 2 weeks of treatment. Falnidamol (50 mg/kg/day for 2 weeks) results in dephosphorylation of the EGF receptor in A431 xenograft-bearing mice. With Falnidamol (p.o.; 10 mg/kg/day; 16 days), the C4h is 2222 nM and the C24h is 244 nM [2]. |
動物実験 | Animal Model: Five- to six-week-old athymic NMRI-nu/nu female mice (21-31 g) with A431, FaDu, or HN5 cells Dosage: 10 mg/kg Administration: p.o.; daily; 16 days Result: Completely suppressed tumor growth of human A431 xenografts with respective T/C values of 15 and 6% after 2 weeks of treatment [2]. |
別名 | BIBX 1382 |
分子量 | 387.84 |
分子式 | C18H19ClFN7 |
CAS No. | 196612-93-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28.8 mg/mL (74.3 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Falnidamol 196612-93-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR BIBX 1382 BIBX-1382 BIBX1382 Inhibitor inhibitor inhibit