Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 7,500 | |||
25 mg | 在庫あり | ¥ 11,500 | |||
50 mg | 在庫あり | ¥ 15,000 | |||
100 mg | 在庫あり | ¥ 27,000 | |||
200 mg | 在庫あり | ¥ 40,000 |
説明 | Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. |
In vitro | Fudosteine (FDS), a unique mucolytic antioxidant, shows a stronger scavenging effect of Peroxynitrite than N-acetyl-cysteine on DCDHF oxidation in vitro and in sputum macrophages, and also on Peroxynitrite-induced BSA nitration. Fudosteine (0.1 mM) reduces Peroxynitrite-enhanced interleukin (IL)-1beta-induced IL-8 release and restores corticosteroid sensitivity defected by Peroxynitrite more potently than those induced by H(2)O(2) in A549 airway epithelial cells. [1] Fudosteine significantly inhibits increases in GRO/CINC-1 at 10-100 mg/kg, and neutrophils and goblet cells at 30 and 100 mg/kg. Fudosteine inhibits goblet cell hyperplasia by inhibiting GRO/CINC-1 production and/or neutrophil migration. [2] Fudosteine treatment reduces the expression levels of p-p38 MAPK and p-ERK in vivo and of p-ERK in vitro. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression and the effects of fudosteine are associated with the inhibition of extracellular signal-related kinase and p38 mitogen-activated protein kinase in vivo and extracellular signal-related kinase in vitro. [3] Fudosteine significantly suppresses blood flow of tracheal microvasculature increased by SO(2) exposure. Fudosteine scavenges superoxide anion generated from rat neutrophils, and enzymatically generated from xanthine oxidase-acetaldehyde reaction. [4] |
In vivo | Fudosteine (500 mg/kg, p.o.) significantly increases the amount of dye excreted into the respiratory tract. Fudosteine increases chloride ion concentration in broncho-alveolar lavage of rats. [5] |
分子量 | 179.24 |
分子式 | C6H13NO3S |
CAS No. | 13189-98-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
You can also refer to dose conversion for different animals. 詳細
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Fudosteine 13189-98-5 Others mucoactive Inhibitor mRNA inhibit MUC5AC cysteine derivative inhibitor