Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.
説明 | Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes. |
植物由来 |
別名 | Lichenic acid, Fumarate, 2-Butenedioic acid, Trans-Butenedioic acid, Donitic acid, Allomaleic acid |
分子量 | 116.07 |
分子式 | C4H4O4 |
CAS No. | 110-17-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (473.73 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble
You can also refer to dose conversion for different animals. 詳細
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Fumaric acid 110-17-8 Metabolism Endogenous Metabolite Lichenic acid inhibit Fumarate 2-Butenedioic acid Trans-Butenedioic acid Donitic acid Inhibitor Allomaleic acid inhibitor