Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
説明 | GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis. |
ターゲット&IC50 | Chk1:1.2 nM |
別名 | ARRY-575, GDC-0575, GDC 0575, ARRY575, GDC0575 |
分子量 | 414.73 |
分子式 | C16H21BrClN5O |
CAS No. | 1196504-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (144.67 mM)
You can also refer to dose conversion for different animals. 詳細
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GDC0575 monohydrochloride 1196504-54-7 Cell Cycle/Checkpoint Chk GDC-0575 Monohydrochloride ARRY-575 GDC-0575 GDC 0575 GDC 0575 Monohydrochloride GDC0575 Monohydrochloride ARRY575 GDC-0575 monohydrochloride ARRY 575 GDC0575 Inhibitor inhibitor inhibit