Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 91,000 | |||
50 mg | 在庫あり | ¥ 135,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 29,500 |
説明 | GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM. |
ターゲット&IC50 | GPR43:9 nM |
In vitro | GLPG0974 inhibits acetate-induced neutrophil migration strongly and inhibits CD11b activation-specific epitope [AE], a neutrophil-based pharmacodynamic marker, in a human whole blood assay[1]. |
In vivo | GLPG0974(5 and 30 mg/kg; oral) exhibits good pharmacokinetic properties in rat with a bioavailability of 47% and dose-dependently increases the plasma exposure[1]. |
別名 | GLPG-0974 |
分子量 | 484.99 |
分子式 | C25H25ClN2O4S |
CAS No. | 1391076-61-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 180 mg/mL (371.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GLPG0974 1391076-61-1 Endocrinology/Hormones GPCR/G Protein GPR GLPG-0974 GLPG 0974 Inhibitor inhibitor inhibit