Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)
説明 | GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM) |
ターゲット&IC50 | K+ channel:7.5 μM |
In vitro | Analysis of antiviral activities indicated that GSK369796 has high anti-DENV activity in the DENV2 replicon expressing cells with EC50 values of 5.06 ± 0.86 μM. The infectivity assays revealed the EC50 values of 3.03 ± 0.35 μM. The mode of action of this compound is through inhibition of autophagy, thereby affecting DENV2 replication. Moreover, this compounds also showed antiviral activity against the rapidly emerging Zika virus (ZIKV) with EC50 values of 2.57 ± 0.09 μM (GSK369796)[1]. |
別名 | N-tert-butylisoquine |
分子量 | 428.78 |
分子式 | C20H24Cl3N3O |
CAS No. | 1010411-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (174.91 mM)
You can also refer to dose conversion for different animals. 詳細
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GSK369796 Dihydrochloride 1010411-21-8 Membrane transporter/Ion channel Microbiology/Virology Potassium Channel Parasite inhibit GSK 369796 Dihydrochloride Inhibitor N-tert-butylisoquine GSK369796 GSK 369796 GSK-369796 Dihydrochloride GSK-369796 KcsA inhibitor