Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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25 mg | 在庫あり | ¥ 8,000 | |||
50 mg | 在庫あり | ¥ 11,000 | |||
100 mg | 在庫あり | ¥ 19,500 | |||
200 mg | 在庫あり | ¥ 30,000 | |||
500 mg | 在庫あり | ¥ 49,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 7,000 |
説明 | Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
ターゲット&IC50 | HMG-CoA:11 nM |
In vitro | In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma. |
In vivo | In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB. |
別名 | ZD 4522 Calcium, ZD4522, Rosuvastatin hemicalcium |
分子量 | 1001.14 |
分子式 | 2(C22H27FN3O6S)Ca |
CAS No. | 147098-20-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (199.77 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rosuvastatin calcium 147098-20-2 Autophagy Membrane transporter/Ion channel Metabolism Potassium Channel HMG-CoA Reductase gene ZD 4522 Calcium lipoprotein Inhibitor ZD-4522 ZD4522 potential repolarization QTc Hsp70 related HMG-CoA Reductase (HMGCR) inhibit durations Rosuvastatin cholesterol hERG cardiac ZD 4522 low-density KcsA Rosuvastatin hemicalcium triglycerides action APDs inhibitor