Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM)
説明 | GSK5182 is a highly selective inverse estrogen-related receptor γ agonist (IC50 : 79 nM) |
ターゲット&IC50 | ERRγ:79 nM (IC50) |
In vitro | Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5[1]. |
In vivo | a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in db/db and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production[2]. |
細胞研究 | Cell Line:The human hepatoma cell line PLC/PRF/5. Concentration:0 μM, 10 μM, 20 μM. Incubation Time:0 hour, 24 hours, 48 hours, 72 hours |
分子量 | 417.54 |
分子式 | C27H31NO3 |
CAS No. | 877387-37-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (143.7 mM)
You can also refer to dose conversion for different animals. 詳細
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GSK5182 877387-37-6 Endocrinology/Hormones Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species Estrogen/progestogen Receptor Estrogen Receptor/ERR GSK-5182 inhibit GSK 5182 Inhibitor inhibitor