Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 15,500 | |||
25 mg | 在庫あり | ¥ 30,500 | |||
50 mg | 在庫あり | ¥ 45,500 | |||
100 mg | 在庫あり | ¥ 76,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner. |
In vitro | HBT1 bound to the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner.?The mode of HBT1 and LY451395 binding to a pocket in the LBD of AMPA-R differed: HBT1, formed hydrogen bonds with S518 in the LBD.?Lower agonistic profile of HBT1 may associate with its lower risks of bell-shaped responses in BDNF production in primary neurons. |
分子量 | 386.39 |
分子式 | C16H17F3N4O2S |
CAS No. | 489408-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.87 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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HBT1 489408-02-8 Neuroscience GluR HBT-1 Ionotropic glutamate receptors BDNF LBD inhibit glutamate HBT 1 AMPA primary neurons S518 iGluR AMPA-R Inhibitor inhibitor