|
T2430 |
HPOB
|
|
Apoptosis
,
HDAC
|
|
|
|
T6920 |
ON123300
|
|
FGFR
,
c-RET
,
JAK
,
CDK
,
PDGFR
,
Src
,
AMPK
|
|
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM). |
|
T5622 |
BAY-218
|
AHR antagonist 1 |
AhR
,
Aryl Hydrocarbon Receptor
|
|
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T26930 |
BW-1370U87
|
1370U 87,1370U-87,1370U87,BW 1370U87 |
|
|
BW-1370U87 is a monoamine oxidase A (MAO-A) inhibitor. BW-1370U87 elevates neurotransmitter amines in the brain over the same dose range at which it exhibits positive activities in animal models of depressive illness. BW... |
|
T8966 |
ML-298
|
ML298,CID53393915 |
Phospholipase
|
|
ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM). |
|
T3213 |
Hematoporphyrin dihydrochloride
|
Hematoporphyrin IX dihydrochloride |
Apoptosis
,
Others
,
Endogenous Metabolite
|
|
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins. |
|
T81184 |
Sec61-IN-4
|
|
|
|
Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1]. |
|
T63624 |
Exatecan-amide-cyclopropanol
|
|
|
|
Exatecan-amide-cyclopropanol is an anticancer agent that inhibits the proliferation of SK-BR-3 cells (IC50: 0.12 nM) and U87 cells (IC50: 0.23 nM). |
|
T78804 |
PI3Kα-IN-12
|
|
PI3K
|
|
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values of 0.83 and 1.25 μM, respectively. Intraperitoneal administr... |
|
T38004 |
ML-309 (hydrochloride)
|
|
|
|
ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate productio... |
|
T81469 |
PI3Kα-IN-14
|
|
PI3K
|
|
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in cell cycle arrest at the G1 phase and apoptosis in U87-MG cel... |
|
T78862 |
EGFR-IN-86
|
|
EGFR
|
|
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1]. |
|
T62060 |
NF-κB-IN-5
|
|
|
|
NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor. NF-κB-IN-5 interacts directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines, with IC 50 values of 5.35, 2.81, 2.83, 2.02 and... |
|
T70890 |
ML309
|
|
|
|
ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers c... |
|
T69438 |
MT477
|
|
|
|
MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (... |
|
T79530 |
SA-PA
|
|
PROTACs
|
|
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-... |
|
T74536 |
IDO/Tubulin-IN-2
|
|
|
|
IDO/Tubulin-IN-2 (HT2) is a powerful inhibitor of both TDO and tubulin. This compound demonstrates significant efficacy against various cancer cell lines, including U87, HepG2, A549, HCT-116, and LO2, with respective IC5... |
|
T79531 |
SA-VA
|
|
PROTACs
|
|
SA-VA, an intracellular self-assembled PROTAC featuring azide and alkyne groups, selectively degrades VEGFR-2 and EphB4 proteins within U87 cells. This compound undergoes in situ conversion to active PROTAC via a copper-... |
|
T36100 |
K-TMZ
|
|
|
|
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lin... |
|
T78773 |
Tubulin inhibitor 38
|
|
|
|
Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell cycle at the G2/M phase, ultimately triggering apoptosis. A... |
|
T83709 |
LIH383 TFA
|
Phe-Gly-Gly-Phe-Met-Arg-Arg-Lys-NH2 |
|
|
LIH383 is a peptide agonist specifically designed to activate the chemokine (C-X-C motif) receptor 7 (CXCR7), which functions both as a chemokine and an opioid peptide scavenger receptor. Demonstrating a high selectivity... |
|
T71261 |
Arsthinol
|
|
|
|
Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a bette... |
|
T36241 |
Arecaidine propargyl ester (hydrobromide)
|
|
|
|
Arecaidine propargyl ester is an agonist of M2muscarinic acetylcholine receptors (mAChRs).1It selectively binds to M2over M1, M3, M4, and M5mAChRs in CHO cells expressing the human receptors (Kis = 0.0871, 1.23, 0.851, 0... |
|
T8968 |
ML299
|
VU0463568,ML-299 |
Phospholipase
|
|
ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively). |
