Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 11,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 39,000 | |||
25 mg | 在庫あり | ¥ 81,000 | |||
50 mg | 在庫あり | ¥ 123,500 | |||
100 mg | 在庫あり | ¥ 178,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,000 |
説明 | HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. |
ターゲット&IC50 | RIP3:20.8 nM |
In vitro | HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action.?Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity.?HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation. |
分子量 | 384.47 |
分子式 | C24H24N4O |
CAS No. | 2158197-70-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (43.36 mM)
You can also refer to dose conversion for different animals. 詳細
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HS-1371 2158197-70-5 Apoptosis NF-Κb RIP kinase Inhibitor Receptor-interacting protein kinases HS1371 RIPK inhibit HS 1371 inhibitor