Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
説明 | Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1. |
In vitro | Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC50 values for 24 and 48 h of Hexahydrocurcumin exposure are 77.05 and 56.95, respectively. Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 expression. The level of COX-1 is not altered [1]. Hexahydrocurcumin (7-14 μM; 24 hours) attenuates LPS-elicited increase of prostaglandin E2 (PGE2) in murine macrophages (RAW 264.7) in a concentration-dependent manner [2]. |
In vivo | In colon cancer rats, Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci. Hexahydrocurcumin also markedly decreases COX-2 protein expression [3]. |
細胞研究 | Cell Line: HT-29 cells. Concentration: 0 μM, 5 μM, 10 μM, 25 μM. Incubation Time: 24 hours or 48 hours [1] |
動物実験 | Animal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH). Dosage: 50 mg/kg. Administration: Oral administration; daily; for 16 weeks [3] |
植物由来 |
分子量 | 374.43 |
分子式 | C21H26O6 |
CAS No. | 36062-05-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (120.19 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Hexahydrocurcumin 36062-05-2 Immunology/Inflammation Metabolism Neuroscience NF-Κb Reactive Oxygen Species ROS COX inhibit Cyclooxygenase Inhibitor inhibitor