Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
1 mg | 在庫あり | ¥ 19,500 | |
5 mg | 在庫あり | ¥ 45,000 | |
10 mg | 在庫あり | ¥ 68,000 | |
25 mg | 在庫あり | ¥ 114,000 | |
50 mg | お問い合わせ | お問い合わせ | |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 48,500 |
説明 | Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes. |
In vitro | Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization[1] |
植物由来 |
分子量 | 366.45 |
分子式 | C22H26N2O3 |
CAS No. | 35467-43-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (150.09 mM)
You can also refer to dose conversion for different animals. 詳細
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Hirsuteine 35467-43-7 GPCR/G Protein Neuroscience Dopamine Receptor Inhibitor inhibit inhibitor