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T2601 |
Vidofludimus
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SC12267,4sc-101 |
Dehydrogenase
,
DNA/RNA Synthesis
,
Interleukin
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Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). |
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T9010 |
IMM-H007
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Others
,
AMPK
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IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression |
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T27460 |
GSK2324
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GSK-2324,GSK 2324 |
FXR
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GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis. |
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T7294 |
Aramchol
|
C20-FABAC |
Others
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Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholester... |
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T78093 |
Cisd2 agonist 1
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Others
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Cisd2 agonist 1 (Compound 4q), with an EC50 of 34 nM, augments Cisd2 expression and ameliorates pathological alterations in fatty liver disease, demonstrating good metabolic stability. This compound is utilized in non-al... |
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T78313 |
Fazpilodemab
|
BFKB8488A |
FGFR
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Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. It is utilized in research pertaining to Type 2 diabetes mellitus (T2DM) and n... |
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T74132 |
GLP-1 receptor agonist 8
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GLP-1 receptor agonist 8, a potent agonist of GLP-1 R, holds potential for diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) research[1]. |
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T62029 |
ML261
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ML261 is a inhibitor of hepatic lipid droplets formation with an IC 50 of 69.7 nM. ML261 has research value in non-alcoholic fatty liver disease (NAFLD) and inflammation. |
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T75150 |
GIP/GLP-1 dual receptor agonist-1
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|
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GIP/GLP-1 dual receptor agonist-1 (compound 4), a receptor agonist for both GIP and GLP-1, shows potential for the research of metabolic disorders and fatty liver diseases, such as nonalcoholic steatohepatitis (NASH) and... |
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T62277 |
PPARδ agonist 8
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Pparδ agonist 8 is a potent agonist of Pparδ. Pparδ agonist 8 has potential for the study of nonalcoholic fatty liver disease (NAFLD). |
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T72889 |
FXR agonist 4
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FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ... |
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T82719 |
Cisd2 agonist 2
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|
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Cisd2 agonist 2 (compound 6), with an EC50 of 191 nM, is an orally active activator of Cisd2, a protein whose levels are associated with nonalcoholic fatty liver disease (NAFLD). In vivo studies have demonstrated that Ci... |
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T78095 |
Demethyleneberberine chloride
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NF-κB
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Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB pathway and modulating the equilibrium of Th cells. It is ... |
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T35443 |
1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
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1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral ... |
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T62052 |
AMPK activator 6
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AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (... |
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T82254 |
GSK-LSD1
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Histone Demethylase
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GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (... |
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T79358 |
PF-07247685
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|
Endogenous Metabolite
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PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages... |
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T79357 |
PF-07238025
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Endogenous Metabolite
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PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 sub... |
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T35881 |
Resolvin E2
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-... |
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T62205 |
Pparδ agonist 7
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Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) belongs to the intranuclear receptor transcription factor superfamily and plays a key role in the regulation of metaboli... |
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T37522 |
Teneligliptin
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Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM.
Teneli... |
