Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 20,500 | |||
10 mg | 在庫あり | ¥ 33,000 | |||
25 mg | 在庫あり | ¥ 68,000 | |||
50 mg | 在庫あり | ¥ 133,000 | |||
100 mg | 在庫あり | ¥ 192,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. |
In vitro | ORY-1001 is a highly potent and selective KDM1A inhibitor that induces H3K4me2 accumulation on KDM1A target genes, blast differentiation, and reduction of leukemic stem cell capacity in AML. |
In vivo | ORY-1001 exhibits potent synergy with standard-of-care drugs and selective epigenetic inhibitors, reduces growth of an AML xenograft model, and extends survival in a mouse PDX (patient-derived xenograft) model of T cell acute leukemia.?Surrogate pharmacodynamic biomarkers developed based on expression changes in leukemia cell lines were translated to samples from patients treated with ORY-1001.?ORY-1001 is a selective KDM1A inhibitor in clinical trials and is currently being evaluated in patients with leukemia and solid tumors. |
別名 | ORY-1001(trans) |
分子量 | 303.27 |
分子式 | C15H24Cl2N2 |
CAS No. | 1431303-72-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.03 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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Iadademstat dihydrochloride 1431303-72-8 Chromatin/Epigenetic Histone Demethylase RO 7051790 RG 6016 RO7051790 inhibit RG6016 Inhibitor ORY1001 RO-7051790 ORY 1001 Iadademstat Dihydrochloride ORY-1001 Iadademstat RG-6016 ORY-1001(trans) inhibitor