Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,000 | |||
10 mg | 在庫あり | ¥ 16,000 | |||
25 mg | 在庫あり | ¥ 29,000 | |||
50 mg | 在庫あり | ¥ 52,000 | |||
100 mg | 在庫あり | ¥ 95,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 15,000 |
説明 | WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
ターゲット&IC50 | Proliferation (β cells):28 nM(ec50) |
In vivo | In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells. |
細胞研究 | R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference) |
分子量 | 569.58 |
分子式 | C28H30F3N7O3 |
CAS No. | 1421227-52-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (163.3 mM)
Ethanol: 74 mg/mL (129.9 mM)
You can also refer to dose conversion for different animals. 詳細
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WS3 1421227-52-2 Angiogenesis JAK/STAT signaling NF-Κb Tyrosine Kinase/Adaptors EGFR IκB/IKK insulin pancreatic pigment proliferation epithelial β cell Inhibitor R7T1 diabete RPE inhibit WS 3 retinal WS-3 inhibitor