store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 60,500 | |||
25 mg | 在庫あり | ¥ 101,000 | |||
50 mg | 在庫あり | ¥ 149,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 44,000 |
説明 | JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. |
ターゲット&IC50 | PRMT5:0.14 nM |
In vitro | JNJ-64619178 displays effective and broad inhibition of cellular growth. JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action [1]. |
In vivo | In several non-small cell lung cancer and small cell lung cancer mouse xenograft models, JNJ-64619178 (p.o.) causes efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome [1]. |
分子量 | 483.36 |
分子式 | C22H23BrN6O2 |
CAS No. | 2086772-26-9 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (248.26 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JNJ-64619178 2086772-26-9 Chromatin/Epigenetic Histone Methyltransferase inhibit JNJ64619178 Inhibitor Onametostat JNJ 64619178 inhibitor