Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
説明 | KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). |
ターゲット&IC50 | CaMK II:370 nM(ki) |
In vitro | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. |
別名 | KN92-H3PO4 |
分子量 | 554.98 |
分子式 | C24H28ClN2O7PS |
CAS No. | 1135280-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (99.1 mM)
You can also refer to dose conversion for different animals. 詳細
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KN-92 phosphate 1135280-28-2 Neuroscience CaMK KN92 phosphate derivative inactive KN 92 phosphate KN 92 Phosphate control Inhibitor KN-92 Phosphate experimental KN92-H3PO4 KN-92 KN 92 inhibit KN92 KN92 Phosphate analog inhibitor