Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.
説明 | Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation. |
ターゲット&IC50 | PKCα:30 μM(baculovirus-infected Sf9 insect cells), PKCη:82 μM(baculovirus-infected Sf9 insect cells), PKCδ:3 μM(Porcine spleen), PKCγ:40 μM(baculovirus-infected Sf9 insect cells), PKA:78 μM, PKCζ:100 μM(baculovirus-infected Sf9 insect cells), PKCε:100 μM(baculovirus-infected Sf9 insect cells), CK2:30 μM(holoenzyme expressed in E.coli), PKCβ:42 μM(baculovirus-infected Sf9 insect cells) |
In vitro | Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2]. |
In vivo | Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3]. |
別名 | Mallotoxin, NSC 56346, NSC 94525 |
分子量 | 516.54 |
分子式 | C30H28O8 |
CAS No. | 82-08-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (3.87 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Rottlerin 82-08-6 Apoptosis Tyrosine Kinase/Adaptors Proteases/Proteasome Autophagy Chromatin/Epigenetic Cytoskeletal Signaling Others Neuroscience Microbiology/Virology PKA PKC HIV Protease CaMK Mallotoxin inhibit NSC94525 Inhibitor Human immunodeficiency virus Protein kinase C NSC-94525 NSC 56346 HIV NSC-56346 NSC56346 NSC 94525 inhibitor