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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6878 | LJI308 | S6 Kinase | |
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. | |||
T8235 | L-732138 | Neurokinin receptor | |
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM) | |||
T16074 | Mifobate | SR-202 | PPAR |
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1]. | |||
T0096 | Vardenafil | Vivanza,Levitra,Vardenafil hydrochloride | PDE |
T8405 | Vardenafil hydrochloride | PDE | |
Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes | |||
T4097 | Vardenafil hydrochloride trihydrate | Vardenafil HCl Trihydrate,BAY38-9456 | PDE |
Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T4480 | Vardenafil dihydrochloride | Levitra,Vardenafil Hydrochloride | PDE |
Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. | |||
T5641 | RP-54745 | Interleukin | |
RP-54745, a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production. | |||
T9544 | Compound 1T-0216 | Others | |
Compound 1T-0216 is a blocker of AKT1-FAK interactions and reduces stimulation of FAK phosphorylation by extracellular stress in human SW620 colon cancer cells without affecting basal FAK phosphorylation. | |||
T4068 | E6446 dihydrochloride | TLR | |
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. | |||
TP2365L | Acetyl tetrapeptide-9 Acetate | Acetyl tetrapeptide-9 Acetate(928006-50-2 Free base) | Others |
Acetyl tetrapeptide-9 Acetate plays a role in the stimulation of basement membrane polysaccharide (lumican) and the synthesis of collagen I. | |||
T1415 | Gemfibrozil | CI-719,Jezil,Decrelip,Lopid | P450 , Adrenergic Receptor , PPAR |
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi... | |||
T23536 | Xamoterol hemifumarate | ICI 118587 hemifumarate,Corwin hemifumarate | Adrenergic Receptor |
Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr... | |||
T9545 | Compound 1T-0219 (SC) | FAK | |
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylati... | |||
T29087 | VA-K-14 hydrochloride | VAK14 Hydrochloride,VA K 14 HCl,VA-K-14 HCl,VAK14 HCl | TSH Receptor |
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogate... | |||
T5327 | Amezinium methylsulfate | Amezinium metilsulfate,Amezinium (methylsulfate),Lu-1631 | Adrenergic Receptor |
Amezinium methylsulfate (Lu-1631) has multiple mechanisms, including stimulation of alpha and beta-1 receptors and inhibition of noradrenaline and tyramine uptake. | |||
T12160 | N6-Cyclohexyladenosine | CHA | Adenosine Receptor |
N6-Cyclohexyladenosine (CHA) is a selective agonist of A1 receptor with EC50 of 8.2 Nm. N6-Cyclohexyladenosine exerts anticonvulsant effects and protects against neuronal death. CHA was also found to inhibit the pressor ... | |||
T13187 | Topterone | Win 17665 | Androgen Receptor |
TP1896L1 | Kisspeptin 234 acetate(1145998-81-7 free base) | GPR , Kisspeptin | |
Kisspeptin 234 acetate(1145998-81-7 free base) is a Kisspeptin receptor (KISS1, GPR54) antagonist; a Kisspeptin-10 analogue. It inhibits the stimulation of inositol phosphate (IP) (IC50 = 7 nM) and the release of gonadot... | |||
T4132 | BPTU | BMS-646786 | P2Y Receptor |
BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced... | |||
T16383 | Olinciguat | IW-1701 | Guanylate cyclase |
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole-cell assay. | |||
T34532 | Sari 59-801 | Sari-59-801 | Others |
Sari 59-801 is a novel, orally effective hypoglycemic compound. | |||
TP1940L1 | Ac-RYYRIK-NH2 acetate | Opioid Receptor | |
Ac-RYYRIK-NH2 acetate is an agonist at nociceptin/orphanin FQ(noc/OFQ) receptors, affecting spontaneous locomotor activity. Ac-RYYRIK-NH2 acetate is a partial agonist on ORL1 transfected in CHO cells, antagonizes the sti... | |||
T13536 | Afoxolaner | Chloride channel , GABA Receptor , Parasite | |
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting i... | |||
T28222 | 5-Hydroxy-1-methylhydantoin | HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419 | Bradykinin Receptor |
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con... | |||
T1281 | Tropicamide | Ro 1-7683 | AChR |
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ... | |||
T4042 | Talabostat mesylate | Val-boroPro,PT100 | Proteasome , DPP-4 |
Talabostat mesylate (PT100) is an orally active, selective inhibitor of dipeptidyl peptidases IV (DPP4, IC50: 0.18 nM), including tumor-associated fibroblast activation protein. This agent may also stimulate the producti... | |||
T21410 | Triptorelin acetate(57773-63-4 free base) | Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003 | GNRH Receptor |
Triptorelin acetate(57773-63-4 free base) (CL 118,532) is used as a GnRH agonist. It decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by causing constant stim... | |||
T68405 | KW-2450 free base | IGF-1R | |
KW-2450 free base is an orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 free ... | |||
T6602 | Naratriptan hydrochloride | Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride | 5-HT Receptor |
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... | |||
TP1219 | Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate | ANP (1-28), human, porcineANP(1-28) | |
TP2365 | Acetyl tetrapeptide-9 | LS9745,N-Acetyl-gln-asp-val-his,Dermican,LS-9745,LS 9745 | |
Acetyl tetrapeptide-9 is important for the stimulation of basement membrane polysaccharide (lumican) and the synthesis of collagen I. | |||
T71051 | OSU-53 | ||
OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF. | |||
T25912 | Oxypyrronium bromide | L.D. 3055,Immetropan,LD 3055,LD3055,LD-3055 | |
Oxypyrronium bromide is an anticholinergic and spasmolytic agent containing quaternary ammonium. In animal models it inhibited gastric motility, hypotension induced by vagus stimulation or intravenation of acetylcholine;... | |||
T33696 | NK-1145 | NK-1145 hydrocholdoride,NK 1145,NK1145 | |
Nk-1145 is a parasympathetic drug of the autonomic nervous system, which can cause behavioral stimulation and excitement. | |||
T24603 | PD-34799-SA | PD 34799-SA,PD34799-SA | |
PD-34799-SA is an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation. | |||
T68782 | Ono 11006 | ||
Ono 11006 is a thromboxane agonist that dose dependently reduced the positive inotropic effect induced by field stimulation. | |||
T19762 | Clobenpropit 2HBr | VUF-9153,VUF 9153,Clobenpropit Dihydrobromide,VUF9153 | |
Clobenpropit 2HBr is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in the brain. | |||
T71863 | LDDN-0003499 | ||
LDDN-0003499 is a novel Src family tyrosine kinase inhibitor with anti-inflammatory effects in response to Aß stimulation of microglia. | |||
T71803 | Mabuterol hydrochloride | ||
Mabuterol hydrochloride is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation. | |||
T28431 | PNU109291 | PNU-109291,PNU 109291 | |
PNU109291, a potent and selective agonist of the 5-HT1D receptor, effectively mitigates dural plasma extravasation induced by trigeminal ganglion stimulation. | |||
T25918 | Palmitoyl-L-aspartic acid | L-N-Palmitoylaspartic acid | |
Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid rec... | |||
T34430 | RU 24411 | RU24411,RU-24411 | |
RU 24411 is a synthetic 19-nor steroid compound. RU 24411 appeared as capable of stimulation of sodium transport as aldosterone in the absence of glucose. | |||
T76646 | Acetyl-ACTH (7-24) (human, bovine, rat) | ||
Acetyl-ACTH (7-24) (human, bovine, rat) effectively inhibits the secretion of corticosterone and aldosterone triggered by ACTH stimulation [1]. | |||
T26959 | Cazpaullone | ||
Cazpaullone is an inhibitor of glycogen synthase kinase-3 (GSK-3). It also shows transient stimulation of the mRNA expression of the beta cell transcription factor Pax4. | |||
T40898 | DMHCA | ||
DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in... | |||
T38641 | AP 811 | ||
AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 81... | |||
TP1896 | Kisspeptin 234 | ||
Kisspeptin 234 is a kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH). | |||
T37268 | PAF C-16 Carboxylic Acid | ||
PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production o... | |||
T71792 | Quipazine maleate | ||
Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of... |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T2198 | Arecoline hydrobromide | Arecoline HBr,Arecoline bromide | AChR |
Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist. | |||
TQ0273 | Neopterin | D-(+)-Neopterin,2-Amino-6-((1S,2R)-1,2,3-trihydroxypropyl)pteridin-4(3H)-one | Endogenous Metabolite |
D-(+)-Neopterin (D-(+)-Neopterin) is produced by human monocytes/macrophages upon stimulation with the cytokine interferon-γ. In humans, neopterin is involved in purine biosynthesis. | |||
T6S1010 | Allomatrine | Others | |
Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord. | |||
T6S0627 | Mesaconitine | TNF | |
1. Mesaconitine has antiinflammatory activity. 2. Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system. | |||
T5814 | Aurantiamide | TMC-58B | p38 MAPK , NF-κB |
Aurantiamide has anti-cancer, anti-inflammatory and antinociceptive activities, it may suppress the growth of malignant gliomas by blocking autophagic flux.Aurantiamide has an anti-neuroinflammatory effect on LPS stimula... | |||
T5S1989 | Apiin | Apioside | Others |
1. Apiin (Apioside) is the reducing and stabilizing agent. 2. Apiin has inhibitory activity in-vitro on iNOS expression and nitrite production when added before LPS stimulation in the medium of J774.A1 cells. | |||
TN1100 | Nepodin | transporter , COX , AMPK , Parasite | |
Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 tra... | |||
T0131 | Cepharanthine | NSC-623442 | Apoptosis , TNF , HIV Protease , Autophagy |
Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production. | |||
TL0007 | Bisdemethoxycurcumin | Curcumin III,Didemethoxycurcumin | Epigenetic Reader Domain , Wnt/beta-catenin |
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac... | |||
T5120 | Rhamnose | 6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose | Calcium Channel , Endogenous Metabolite |
Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind... | |||
T20879 | Tacrolimus monohydrate | FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,FK 506 | Phosphatase , Others , Antibacterial , Antibiotic , Autophagy |
Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, whi... | |||
T3874 | Diosgenin glucoside | Disogluside,Trillin | Apoptosis , Others , Autophagy |
Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis an... | |||
T5S1177 | Aloin B | Isobarbaloin | Others |
Aloin B (Isobarbaloin) is an isomer of aloin.1. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation, the result opens new ... | |||
T4S0867 | Pogostone | DHELWANGIN | Apoptosis , Antibacterial , Autophagy |
1. Pogostone (DHELWANGIN) possesses potent anti-bacterial and anti-fungal activities, such as gram negative bacteria , gram positive bacteria, Escherichia coli. 2. Pogostone exhibits an immunosuppressive property by dire... | |||
T6S2140 | β-Anhydroicaritin | Anhydroicaritin,Beta-Anhydroicaritin | MMP , Others , TNF , Interleukin |
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ... | |||
T3S0860 | Gitogenin | UGT | |
1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of e... | |||
T3S1612 | Kuwanon G | Moracenin B,Kuwanone G | Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase |
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a... | |||
TN6442 | Esculentoside C | ||
Esculentoside C exerts proinflammatory effects synergistically, it can induce inflammatory stimulation. | |||
TN4986 | Selinidin | IκB/IKK , p38 MAPK , TNF | |
Selinidin decreases phosphorylation of phospholipase C-gamma1, p38 mitogen-activated protein kinase, and IkappaB-alpha upon FcepsilonRI stimulation. | |||
TN1533 | Cucurbitacin A | ROCK | |
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase. | |||
TN2001 | Oblongine | Others | |
Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by α²-adrenergic receptor stimulation. | |||
TN3744 | Cyclomorusin | NOS , AChR | |
Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophi... | |||
TN4624 | Nantenine | Others | |
Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulati... | |||
T83319 | 4-epi-Withaferin A | ||
4-epi-Withaferin A (compound 28), an analogue of Withaferin A, exhibits enhanced cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). It shows promise for the investigation of protein aggregation-associate... | |||
TN4489 | Manassantin A | ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT | |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio... | |||
TN4291 | Isofuranodiene | IL Receptor , NOS | |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPH-01031 | CAPN2 Protein, Human, Recombinant (His) | Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cle... | |||
TMPJ-01464 | IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F) | Human | HEK293 Cells |
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m... | |||
TMPJ-00090 | FGF-9 Protein, Human, Recombinant | Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inc... | |||
TMPY-04552 | AKT1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ... | |||
TMPY-04125 | PTP1B Protein, Human, Recombinant (His) | Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c... | |||
TMPY-01850 | CEACAM3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66... | |||
TMPJ-01210 | IL-33 Protein, Mouse, Recombinant | Mouse | E. coli |
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-01648 | TREML2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like... | |||
TMPY-02028 | RON/CD136 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. ... | |||
TMPJ-01011 | FGF-9 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine a... | |||
TMPK-00076 | IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated | Human | E. coli |
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop... | |||
TMPK-00317 | IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I... | |||
TMPK-00512 | IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His) | Cynomolgus | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I... | |||
TMPK-00853 | ENPP1 Protein, Human, Recombinant (N-His) | Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP... | |||
TMPK-00852 | ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP... | |||
TMPJ-00024 | GMF beta/GMFB Protein, Human, Recombinant (His) | Human | E. coli |
Glia maturation factor beta (GMFB) contains a ADF-H domain,which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis and... | |||
TMPK-00144 | CEACAM3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The human granulocyte-specific receptor carcinoembryonic antigen-related cell adhesion molecule (CEACAM)3 is critically involved in the opsonin-independent recognition of several bacterial pathogens. CEACAM3-mediated pha... | |||
TMPK-00316 | IL-18R alpha Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells |
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I... | |||
TMPH-02277 | PTPN11 Protein, Human, Recombinant (T253M & Q257L, His) | Human | E. coli |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosph... | |||
TMPH-03287 | EPOR Protein, Rat, Recombinant (His & SUMO) | Rat | E. coli |
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also ... | |||
TMPK-00781 | ENPP1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP... | |||
TMPH-03440 | RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) | Saccharomyces cerevisiae | E. coli |
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His ... | |||
TMPH-02650 | FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory... | |||
TMPH-03749 | CYSLTR1 Protein, Human, Recombinant (His) | Human | E. coli |
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and... | |||
TMPJ-00415 | HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated | Human | HEK293 Cells |
Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un... | |||
TMPK-00854 | ENPP1 Protein, Human, Recombinant (C-His) | Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (eP... | |||
TMPJ-00525 | LGALS14 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind β-Galactoside. LGALS14 is expressed intr... | |||
TMPK-00053 | GITR Ligand/TNFSF18 Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPJ-00438 | SECTM1A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
SECTM1A (secreted and transmembrane 1A), is 192 amino acid (aa) protein, appears to share structural and functional characteristics with other SECTM1 proteins. Human SECTM1 can be found either found as an approximately 2... | |||
TMPK-00035 | IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In t... | |||
TMPK-00837 | Galectin-3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain.Galact... | |||
TMPH-02022 | RXFP2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). RXFP2 Pro... | |||
TMPJ-01117 | INPP5A Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Type I inositol 1,4,5-trisphosphate 5-phosphatase is a 412 amino acids protein that belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme ... | |||
TMPK-00329 | TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated | Human | HEK293 Cells |
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign... | |||
TMPK-01018 | B7-H3 Protein, Human, Recombinant (aa 29-245, His) | Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s... | |||
TMPK-00977 | AMHRII Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women under... | |||
TMPK-01064 | GITR Ligand/TNFSF18 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due... | |||
TMPH-03207 | IL-2 Protein, Rabbit, Recombinant (His) | Rabbit | E. coli |
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes... | |||
TMPJ-01456 | Mucin-17/MUC17 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Mucins are key components of the mucosal barrier in the stomach that protects epithelia from carcinogenic effects of chronic inflammation. Analysis of The Cancer Genome Atlas database indicated that mucin17 (MUC17) was m... | |||
TMPH-01207 | DOCK8 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally a... | |||
TMPH-02540 | GRK2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to... | |||
TMPJ-00005 | CCL3 Protein, Human, Recombinant | Human | E. coli |
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits che... | |||
TMPH-02218 | JUN Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali... | |||
TMPH-02442 | IL-2 Protein, Rhesus macaque, Recombinant (His & Myc & SUMO) | Rhesus | E. coli |
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes... | |||
TMPH-02441 | IL-15 Protein, Rhesus macaque, Recombinant (His) | Rhesus | P. pastoris (Yeast) |
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimula... | |||
TMPY-03216 | GMF beta/GMFB Protein, Human, Recombinant | Human | E. coli |
GMFB is a nerve growth factor which belongs to the actin-binding proteins ADF family, GMF subfamily. GMFB is involved in nervous system development, angiogenesis and immune function. It is especially crucial for the nerv... | |||
TMPK-00767 | SLPI Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation... | |||
TMPH-02219 | JUN Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali... | |||
TMPK-01016 | B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled | Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount s... | |||
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カタログ番号 | 製品名 | ||
---|---|---|---|
L7900 | Osteogenesis Compound Library | 317 compounds | |
A unique collection of 317 osteogenesis related compounds for high throughput and high content screening; |