Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 18,500 | |||
50 mg | 在庫あり | ¥ 35,500 | |||
100 mg | 在庫あり | ¥ 56,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,000 |
説明 | Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep. |
In vivo | In vivo, Lorediplon inhibits spontaneous motor activity and increases the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity [1]. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice [2]. |
分子量 | 394.42 |
分子式 | C20H15FN4O2S |
CAS No. | 917393-39-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (253.54 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Lorediplon 917393-39-6 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor inhibit Inhibitor Gamma-aminobutyric acid Receptor inhibitor