Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 17,000 | |||
25 mg | 在庫あり | ¥ 35,500 | |||
50 mg | 在庫あり | ¥ 59,000 | |||
100 mg | 在庫あり | ¥ 88,500 | |||
200 mg | 在庫あり | ¥ 133,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 14,000 |
説明 | ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively[1]. |
ターゲット&IC50 | ZIKV:52.99 μM (IC50), DENV-2:8.3 μM (IC50) |
In vitro |
ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1]. ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1]. |
別名 | Mucolipin synthetic agonist 1 |
分子量 | 362.42 |
分子式 | C22H22N2O3 |
CAS No. | 332382-54-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17 mg/mL (46.90 mM)
You can also refer to dose conversion for different animals. 詳細
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ML-SA1 332382-54-4 Membrane transporter/Ion channel Others TRP/TRPV Channel lysosomal ML SA1 Inhibitor inhibit protease Transient receptor potential channels autophagy broad-spectrum selective Mucolipin synthetic agonist 1 acidification Zika MLSA1 ML-SA-1 antiviral TRP Channel virus Dengue inhibitor