Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
説明 | MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors. |
In vitro | In A549 cells, MCP110 (20 μM) decreases Ras stimulation of Raf-1 and cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL), and serum. In in HEK293 cells, MCP110 (10 and 20 μM) inhibits H-Ras (V12)-induced AP-1 activation. In fibrosarcoma HT1080 cells, MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity[1]. |
別名 | MCP-110, MCP 110 |
分子量 | 508.65 |
分子式 | C33H36N2O3 |
CAS No. | 521310-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (481.67 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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MCP110 521310-51-0 GPCR/G Protein MAPK Raf Ras astrocytomas Inhibitor Raf kinases colorectal cancer MCP-110 inhibit Raf-1 MCP 110 inhibitor