Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MS402 is a novel BD1-selective BET BrD inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 22,500 | |||
25 mg | 在庫あり | ¥ 45,500 | |||
50 mg | 在庫あり | ¥ 72,000 | |||
100 mg | 在庫あり | ¥ 122,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 17,500 |
説明 | MS402 is a novel BD1-selective BET BrD inhibitor. |
ターゲット&IC50 | BRD3 BD1:110 nM (Ki), BRD4 BD2:718 nM (Ki), BRD4 BD1:77 nM (Ki), BRD3 BD2:200 nM (Ki), BRD2 BD2:240 nM (Ki), BRD2 BD1:83 nM (Ki) |
In vitro | MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment. |
分子量 | 370.83 |
分子式 | C20H19ClN2O3 |
CAS No. | 1672684-68-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (60.67 mM)
You can also refer to dose conversion for different animals. 詳細
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MS402 1672684-68-2 Chromatin/Epigenetic Epigenetic Reader Domain inhibit Inhibitor MS-402 MS 402 inhibitor