Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneous leishmaniasis, however a 2005 survey concluded that miltefosine is the only effective oral treatment for both forms of leishmaniasis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 11,000 | |||
100 mg | 在庫あり | ¥ 13,000 | |||
200 mg | 在庫あり | ¥ 19,500 | |||
500 mg | 在庫あり | ¥ 27,000 |
説明 | Miltefosine (HePC) is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agents produce some potency against visceral or cutaneous leishmaniasis, however a 2005 survey concluded that miltefosine is the only effective oral treatment for both forms of leishmaniasis. |
ターゲット&IC50 | PKC:7 μM |
キナーゼ試験 | Levels of enzymatically active caspase-3 are quantified using the ApoAlert Caspase Fluorescent assay kit. Briefly, 1×106 BC-1 PEL cells are treated with 50 μM Miltefosine, 50 μM Perifosine, or 20 nM NVP-BEZ235, as well as the respective vehicle controls. Cells are harvested and lysed 12 hours later. Equivalent micrograms of cell lysate for all samples are incubated with a fluorogenic caspase-3 substrate (DEVD-AFC). Cleavage of DEVD by caspase-3 releases AFC, the fluorescence of which is measured using a FLUOstar OPTIMA fluorometer, with excitation and emission filter wavelengths set to 400 and 505 nm, respectively[3]. |
細胞研究 | 2 × 105 PEL cells are treated with the therapeutic compounds at the indicated doses or with appropriate vehicle as a negative control. Cells are followed for 96 hours, and cell viability is determined by trypan blue exclusion performed in quadruplicate. (Only for Reference) |
別名 | HePC, Hexadecyl phosphocholine |
分子量 | 407.57 |
分子式 | C21H46NO4P |
CAS No. | 58066-85-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
You can also refer to dose conversion for different animals. 詳細
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Miltefosine 58066-85-6 Chromatin/Epigenetic Cytoskeletal Signaling Microbiology/Virology PI3K/Akt/mTOR signaling Proteases/Proteasome Akt HIV Protease PKC HePC PKB inhibit HIV Inhibitor Protein kinase B Hexadecyl phosphocholine Human immunodeficiency virus inhibitor