Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction.
説明 | NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53 interaction. |
ターゲット&IC50 | p53-MDM2:120 nM (ki) |
In vitro | Due to the functional activation of p53, NSC 66811 (0, 5, 10, 20 μM) dose-dependently induces the accumulation of p53, MDM2, and p21cip1/waf. |
分子量 | 340.42 |
分子式 | C23H20N2O |
CAS No. | 6964-62-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL (290.81 mM)
You can also refer to dose conversion for different animals. 詳細
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NSC 66811 6964-62-1 Apoptosis Mdm2 MDM2 HCT-116 MDM-2/p53 Inhibitor NSC-66811 inhibit p53 NSC66811 inhibitor