Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
説明 | Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. |
ターゲット&IC50 | CXCR2 (rat):0.2 nM (Kd), CXCR2 (mouse):0.2 nM (Kd), CXCR1 (cynomolgus):41 nM (Kd), [125I]-CXCL8-CXCR2:0.97 nM (IC50), CXCR2 (cynomolgus):0.08 nM (Kd), [125I]-CXCL8-CXCR1:43 nM (IC50) |
In vitro | Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1]. |
別名 | MK-7123, SCH 527123 |
分子量 | 397.42 |
分子式 | C21H23N3O5 |
CAS No. | 473727-83-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (125.81 mM)
You can also refer to dose conversion for different animals. 詳細
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Navarixin 473727-83-2 Autophagy GPCR/G Protein Immunology/Inflammation CXCR inhibit MK 7123 CXC chemokine receptors MK-7123 Inhibitor MK7123 SCH 527123 SCH527123 SCH-527123 inhibitor