Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 73,500 | |||
50 mg | 在庫あり | ¥ 118,000 | |||
100 mg | 在庫あり | ¥ 171,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. |
In vitro | ON 013100 effectively inhibits the proliferation of various cancer cell lines, including mantle cell lymphoma (MCL; JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, FLO-1) at nanomolar concentrations (ON 013100 GI50=6.7-11.2 nM). It significantly modifies the cell cycle distribution, notably increasing the population of cells at the G2/M phase, with treatment at just 0.1 μM leading to G2/M phase arrest. Additionally, ON-013100 triggers apoptosis, demonstrating broad-spectrum anti-cancer activity in vitro[2][3]. |
分子量 | 394.44 |
分子式 | C19H22O7S |
CAS No. | 865783-95-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (63.38 mM)
You can also refer to dose conversion for different animals. 詳細
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ON-013100 865783-95-5 Cell Cycle/Checkpoint CDK inhibit Inhibitor ON 013100 Cyclin dependent kinase ON013100 inhibitor