Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.
説明 | ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity. |
In vitro | ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC).??ONC206 inhibited cellular proliferation in a dose-dependent manner and was more potent than ONC201 in the ARK1 (IC50 = 0.33 M vs. IC50 = 1.59uM) and SPEC-2 (IC50 = 0.24uM vs. IC50 = 0.81uM) cell lines.?Treatment with ONC206 resulted in induction of ROS production and reduction of mitochondrial membrane potential, accompanied by an increase in cleaved caspase-3 and caspase-9 activity (p |
In vivo | ONC206 (100 mg/kg; p.o.; every 10 days) reduces obviously tumor growth inhibition[2]. |
分子量 | 408.44 |
分子式 | C23H22F2N4O |
CAS No. | 1638178-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (244.83 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ONC206 1638178-87-6 GPCR/G Protein Neuroscience Dopamine Receptor antagonist Inhibitor ONC201 DRD2/3/4 inhibit receptors D2-like ONC 206 dopamine ONC-206 inhibitor